BDBM480609 1-(7-fluoro-3-(1-methyl- 1H-pyrazol-3- yl)isoquinolin-8-yl)-5,7- dimethyl-3-(tetrahydro-2H- pyran-4-yl)-7,8- dihydroimidazo[1,5a] pyrazin-6(5H)-one::US10899769, Example 90a::US10899769, Example 90b
SMILES CC1C(=O)N(C)Cc2c(nc(C3CCOCC3)n12)-c1c(F)ccc2cc(ncc12)-c1ccn(C)n1
InChI Key InChIKey=UMQADUCCACBHKD-UHFFFAOYSA-N
Data 4 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 4 hits for monomerid = 480609
TargetBromodomain-containing protein 4 [49-170](Homo sapiens (Human))
Board of Regents, The University of Texas System
US Patent
Board of Regents, The University of Texas System
US Patent
Affinity DataIC50: 1.01E+3nMAssay Description:BRD4: 2.5 nM of BRD4(49-170) and 10 nM biotin-H4(1-21) Ac-K5/8/12/16 (AnaSpec. 64989) were incubated with varying concentrations of CBP inhibitors in...More data for this Ligand-Target Pair
TargetCREB-binding protein [1081-1197](Homo sapiens (Human))
Board of Regents, The University of Texas System
US Patent
Board of Regents, The University of Texas System
US Patent
Affinity DataIC50: 879nMAssay Description:CBP: 5 nM GST-CBP(1081-1197) and 20 nM biotin-H4(1-21) Ac-K5/8/12/16 (AnaSpec. 64989) were incubated with varying concentrations of CBP inhibitors in...More data for this Ligand-Target Pair
TargetBromodomain-containing protein 4 [49-170](Homo sapiens (Human))
Board of Regents, The University of Texas System
US Patent
Board of Regents, The University of Texas System
US Patent
Affinity DataIC50: 4nMAssay Description:BRD4: 2.5 nM of BRD4(49-170) and 10 nM biotin-H4(1-21) Ac-K5/8/12/16 (AnaSpec. 64989) were incubated with varying concentrations of CBP inhibitors in...More data for this Ligand-Target Pair
TargetCREB-binding protein [1081-1197](Homo sapiens (Human))
Board of Regents, The University of Texas System
US Patent
Board of Regents, The University of Texas System
US Patent
Affinity DataIC50: 2.50E+4nMAssay Description:CBP: 5 nM GST-CBP(1081-1197) and 20 nM biotin-H4(1-21) Ac-K5/8/12/16 (AnaSpec. 64989) were incubated with varying concentrations of CBP inhibitors in...More data for this Ligand-Target Pair