BDBM480973 US10906888, Example 190

SMILES O=C(N1CCCCC1)c1cnc(NC2(CC2)c2cncnc2)nc1

InChI Key InChIKey=VOUQAHAFVBDVGU-UHFFFAOYSA-N

Data  9 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 480973   

TargetPantetheinase(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM480973(US10906888, Example 190)
Affinity DataIC50:  12.5nMAssay Description:The test inhibitors were solubilized in DMSO to a stock concentration of 30 mM. On the day of the assay, dose response plates were prepared by diluti...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPantetheinase(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM480973(US10906888, Example 190)
Affinity DataIC50:  13nMAssay Description:Inhibition of recombinant N-terminal FLAG/His6-tagged human vanin-1 expressed in CHO cells using Pantetheine-7-amino-4-trifluoromethykournarin as sub...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPantetheinase(Mus musculus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM480973(US10906888, Example 190)
Affinity DataIC50:  10nMAssay Description:Inhibition of mouse vanin-1More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPantetheinase(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM480973(US10906888, Example 190)
Affinity DataIC50:  12nMAssay Description:Inhibition of human plasma vanin-1 using pantetheine-7-amino-4-trifluoromethykournarin as substrate preincubated for 30 mins followed by substrate ad...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCaspase-3(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM480973(US10906888, Example 190)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of caspase-3 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPantetheinase(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM480973(US10906888, Example 190)
Affinity DataKd:  20nMAssay Description:Binding affinity to recombinant N-terminal FLAG/His6-tagged human vanin-1 expressed in CHO cells assessed as dissociation constant by surface plasmon...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPantetheinase(Homo sapiens (Human))
Pfizer

US Patent
LigandPNGBDBM480973(US10906888, Example 190)
Affinity DataIC50:  115nMAssay Description:Inhibition of recombinant N-terminal FLAG/His6-tagged human vanin-1 expressed in CHO cells at 10 uM by 1H NMR analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCaspase-1(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM480973(US10906888, Example 190)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of caspase-1 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCaspase-2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM480973(US10906888, Example 190)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of caspase-2 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBiotinidase(Homo sapiens)
Pfizer

Curated by ChEMBL
LigandPNGBDBM480973(US10906888, Example 190)
Affinity DataIC50:  1.80E+4nMAssay Description:Inhibition of N-terminal FLAG/His6-tagged human biotinidase expressed in COS cells using biotinyl-7-amino-4-trifluoromethylcoumarin as substrate prei...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed