BDBM48319 4-amino-2-hydroxy-benzoic acid::4-amino-2-hydroxybenzoic acid::4-azanyl-2-oxidanyl-benzoic acid::Aminosalicylic Acid::ISONICOTINIC ACID HYDRAZIDE P-AMINOSALICYLATE SALT::MLS000069579::P-AMINOSALICYLIC ACID::Parasal::SMR000058830::cid_11988145

SMILES Nc1ccc(C(O)=O)c(O)c1

InChI Key InChIKey=WUBBRNOQWQTFEX-UHFFFAOYSA-N

Data  2 KI  4 IC50  4 Kd

PDB links: 5 PDB IDs match this monomer.

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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 48319   

TargetCarbonic anhydrase 1(Homo sapiens (Human))
Ataturk University

Curated by ChEMBL
LigandPNGBDBM48319(4-amino-2-hydroxy-benzoic acid | 4-amino-2-hydroxy...)
Affinity DataKi:  2.40E+5nMAssay Description:Inhibition of human carbonic anhydrase 1 esterase activity by noncompetitive Lineweaver-Burk plotMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Ataturk University

Curated by ChEMBL
LigandPNGBDBM48319(4-amino-2-hydroxy-benzoic acid | 4-amino-2-hydroxy...)
Affinity DataKi:  1.23E+6nMAssay Description:Inhibition of human carbonic anhydrase 2 esterase activity by non-competitive Lineweaver-Burk plotMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM48319(4-amino-2-hydroxy-benzoic acid | 4-amino-2-hydroxy...)
Affinity DataKd:  1.20E+6nMAssay Description:Protein-tyrosine phosphatase 1B (PTP 1B) site 2 Ligands were identified using [13C]-labeled protein and their Dissociation Constants were determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM48319(4-amino-2-hydroxy-benzoic acid | 4-amino-2-hydroxy...)
Affinity DataKd:  1.20E+3nMAssay Description:Dissociation constant of the compound against protein tyrosine phosphatase PTB1B receptor was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM48319(4-amino-2-hydroxy-benzoic acid | 4-amino-2-hydroxy...)
Affinity DataKd:  1.20E+6nMAssay Description:Binding affinity to N-terminal GST-fused human PTP1B (1 to 288 residues) expressed in Escherichia coli BL21(DE3) by HSQC NMR analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Ataturk University

Curated by ChEMBL
LigandPNGBDBM48319(4-amino-2-hydroxy-benzoic acid | 4-amino-2-hydroxy...)
Affinity DataIC50:  7.50E+5nMAssay Description:Inhibition of human carbonic anhydrase 2 esterase activity by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM48319(4-amino-2-hydroxy-benzoic acid | 4-amino-2-hydroxy...)
Affinity DataKd:  1.20E+6nMAssay Description:Dissociation constant for Protein-tyrosine phosphatase 1BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor beta(Homo sapiens (Human))
Emory University

Curated by PubChem BioAssay
LigandPNGBDBM48319(4-amino-2-hydroxy-benzoic acid | 4-amino-2-hydroxy...)
Affinity DataIC50:  1.37E+4nMAssay Description:NIH Molecular Libraries Screening Centers Network [MLSCN] Emory Chemical Biology Discovery Center in MLSCN Assay provider: John A. Katzenellenbogen, ...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetEstrogen receptor beta(Homo sapiens (Human))
Emory University

Curated by PubChem BioAssay
LigandPNGBDBM48319(4-amino-2-hydroxy-benzoic acid | 4-amino-2-hydroxy...)
Affinity DataIC50:  6.82E+3nMAssay Description:NIH Molecular Libraries Screening Centers Network [MLSCN] Emory Chemical Biology Discovery Center in MLSCN Assay provider: John A. Katzenellenbogen, ...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetCarbonic anhydrase 1(Homo sapiens (Human))
Ataturk University

Curated by ChEMBL
LigandPNGBDBM48319(4-amino-2-hydroxy-benzoic acid | 4-amino-2-hydroxy...)
Affinity DataIC50:  1.30E+5nMAssay Description:Inhibition of human carbonic anhydrase 1 esterase activity by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed