BDBM4851 (4-chlorophenyl)-[4-(4-pyridylmethyl)phthalazin-1-yl]amine::(A) PTK787::CGP 79787::CHEMBL101253::CHEMBL75232::N-(4-chlorophenyl)-4-(pyridin-4-ylmethyl)-1-phthalazinamine::N-(4-chlorophenyl)-4-(pyridin-4-ylmethyl)phthalazin-1-amine::PTK-787::PTK787::ZK222584::cid_151194

SMILES Clc1ccc(Nc2nnc(Cc3ccncc3)c3ccccc23)cc1

InChI Key InChIKey=YCOYDOIWSSHVCK-UHFFFAOYSA-N

Data  3 KI  79 IC50  778 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 860 hits for monomerid = 4851   

TargetMast/stem cell growth factor receptor Kit(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM4851(cid_151194 | PTK787 | CHEMBL101253 | N-(4-chloroph...)
Affinity DataKd:  5.10nMAssay Description:Binding constant for KIT kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetMast/stem cell growth factor receptor Kit(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM4851(cid_151194 | PTK787 | CHEMBL101253 | N-(4-chloroph...)
Affinity DataKd:  5.10nMAssay Description:Binding affinity to human KIT incubated for 1 hr by kinase binding assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/7/2013
Entry Details Article
PubMed
TargetMast/stem cell growth factor receptor Kit(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM4851(cid_151194 | PTK787 | CHEMBL101253 | N-(4-chloroph...)
Affinity DataKd:  5.10nMAssay Description:Binding constant for KIT kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2012
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 1(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM4851(cid_151194 | PTK787 | CHEMBL101253 | N-(4-chloroph...)
Affinity DataKd:  9.60nMAssay Description:Binding constant for FLT1 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 1(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM4851(cid_151194 | PTK787 | CHEMBL101253 | N-(4-chloroph...)
Affinity DataKd:  9.60nMpH: 7.4 T: 2°CAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2009
Entry Details
PCBioAssay
TargetVascular endothelial growth factor receptor 1(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM4851(cid_151194 | PTK787 | CHEMBL101253 | N-(4-chloroph...)
Affinity DataKd:  9.60nMAssay Description:Binding constant for FLT1 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2012
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM4851(cid_151194 | PTK787 | CHEMBL101253 | N-(4-chloroph...)
Affinity DataIC50: 15nMAssay Description:Inhibitory activity against VEGF stimulated autophosphorylation of VEGFR2 expressed in KDR15 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM4851(cid_151194 | PTK787 | CHEMBL101253 | N-(4-chloroph...)
Affinity DataIC50: 16nMAssay Description:Inhibition of VEGFR induced autophosphorylation of human Vascular endothelial growth factor receptor 2 (VEGFR2) transfected in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM4851(cid_151194 | PTK787 | CHEMBL101253 | N-(4-chloroph...)
Affinity DataIC50: 16nMAssay Description:Inhibition of VEGF-induced VEGFR2 phosphorylation expressed in CHO cells in presence of 8 uM ATP by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM4851(cid_151194 | PTK787 | CHEMBL101253 | N-(4-chloroph...)
Affinity DataIC50: 16nMAssay Description:Inhibition of VEGF-induced phosphorylation of VEGFR2 by cell-based ELISA in presence of 8 uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM4851(cid_151194 | PTK787 | CHEMBL101253 | N-(4-chloroph...)
Affinity DataIC50: 17nMAssay Description:Inhibition of VEGF-induced human VEGFR2 autophosphorylation expressed in HUVEC cells measured after 2 hrs by chemiluminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetMast/stem cell growth factor receptor Kit(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM4851(cid_151194 | PTK787 | CHEMBL101253 | N-(4-chloroph...)
Affinity DataKd:  17nMAssay Description:Binding constant for KIT(V559D) kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetMast/stem cell growth factor receptor Kit(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM4851(cid_151194 | PTK787 | CHEMBL101253 | N-(4-chloroph...)
Affinity DataKd:  17nMAssay Description:Binding constant for KIT(V559D) kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2012
Entry Details Article
PubMed
TargetMacrophage colony-stimulating factor 1 receptor(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM4851(cid_151194 | PTK787 | CHEMBL101253 | N-(4-chloroph...)
Affinity DataKd:  18nMAssay Description:Binding constant for CSF1R kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2012
Entry Details Article
PubMed
TargetMacrophage colony-stimulating factor 1 receptor(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM4851(cid_151194 | PTK787 | CHEMBL101253 | N-(4-chloroph...)
Affinity DataKd:  18nMpH: 7.4 T: 2°CAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/14/2009
Entry Details
PCBioAssay
TargetVascular endothelial growth factor receptor 2(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM4851(cid_151194 | PTK787 | CHEMBL101253 | N-(4-chloroph...)
Affinity DataIC50: 20nMAssay Description:Inhibition of VEGFR2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/17/2016
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM4851(cid_151194 | PTK787 | CHEMBL101253 | N-(4-chloroph...)
Affinity DataIC50: 21nMAssay Description:Inhibition of VEGFR2 by cell-based assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM4851(cid_151194 | PTK787 | CHEMBL101253 | N-(4-chloroph...)
Affinity DataIC50: 21nMAssay Description:Inhibition of VEGFR2 in 293 adenovirus transfected kidney cells by cell-based ELISA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM4851(cid_151194 | PTK787 | CHEMBL101253 | N-(4-chloroph...)
Affinity DataIC50: 21nMAssay Description:Inhibition of VEGFR2 expressed in HEK293 cells assessed as inhibition of receptor phosphorylation by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM4851(cid_151194 | PTK787 | CHEMBL101253 | N-(4-chloroph...)
Affinity DataIC50: 21nMAssay Description:Inhibition of VEGF-induced phosphorylation of VEGFR2 by cell-based ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor beta(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM4851(cid_151194 | PTK787 | CHEMBL101253 | N-(4-chloroph...)
Affinity DataKd:  25nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/21/2011
Entry Details
PCBioAssay
TargetPlatelet-derived growth factor receptor beta(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM4851(cid_151194 | PTK787 | CHEMBL101253 | N-(4-chloroph...)
Affinity DataKd:  25nMAssay Description:Binding constant for PDGFRB kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2012
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor beta(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM4851(cid_151194 | PTK787 | CHEMBL101253 | N-(4-chloroph...)
Affinity DataKd:  25nMAssay Description:Binding constant for PDGFRB kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM4851(cid_151194 | PTK787 | CHEMBL101253 | N-(4-chloroph...)
Affinity DataIC50: 34nMAssay Description:Inhibition of VEGF-induced human VEGFR2 autophosphorylation transfected in CHO cells measured after 2 hrs by chemiluminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM4851(cid_151194 | PTK787 | CHEMBL101253 | N-(4-chloroph...)
Affinity DataIC50: 37nMAssay Description:Inhibition of recombinant VEGFR2 after 1 hr by fluorescence polarization assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/14/2011
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM4851(cid_151194 | PTK787 | CHEMBL101253 | N-(4-chloroph...)
Affinity DataIC50: 37nMAssay Description:The in vitro kinase assays were performed in 96-well plates using the recombinant GST-fused kinase domains expressed in baculovirus and purified over...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/9/2005
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM4851(cid_151194 | PTK787 | CHEMBL101253 | N-(4-chloroph...)
Affinity DataIC50: 37nMAssay Description:Inhibition of Vascular endothelial growth factor receptor 2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM4851(cid_151194 | PTK787 | CHEMBL101253 | N-(4-chloroph...)
Affinity DataIC50: 37nMAssay Description:Inhibition of KDR by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/15/2012
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM4851(cid_151194 | PTK787 | CHEMBL101253 | N-(4-chloroph...)
Affinity DataIC50: 42nMAssay Description:Inhibition of VEGFR2More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/20/2011
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM4851(cid_151194 | PTK787 | CHEMBL101253 | N-(4-chloroph...)
Affinity DataIC50: 42nMAssay Description:Inhibition of VEGFR2 by HTRF assay in presence of 8 uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM4851(cid_151194 | PTK787 | CHEMBL101253 | N-(4-chloroph...)
Affinity DataIC50: 42nMAssay Description:Inhibition of VEGFR2 assessed as blockade of pGAT-biotin phosphorylation in presence of 8 uM ATP by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM4851(cid_151194 | PTK787 | CHEMBL101253 | N-(4-chloroph...)
Affinity DataIC50: 42nMAssay Description:In vitro inhibition of Vascular endothelial growth factor receptor 2 (VEGFR-2) expressed in baculovirusMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/27/2012
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM4851(cid_151194 | PTK787 | CHEMBL101253 | N-(4-chloroph...)
Affinity DataIC50: 43nMAssay Description:Inhibition of VEGFR2More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM4851(cid_151194 | PTK787 | CHEMBL101253 | N-(4-chloroph...)
Affinity DataIC50: 43nMAssay Description:Inhibition of VEGFR-2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/2/2017
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM4851(cid_151194 | PTK787 | CHEMBL101253 | N-(4-chloroph...)
Affinity DataIC50: 43nMAssay Description:Inhibition of VGFR-2 (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2020
Entry Details Article
PubMed
TargetMacrophage colony-stimulating factor 1 receptor(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM4851(cid_151194 | PTK787 | CHEMBL101253 | N-(4-chloroph...)
Affinity DataKd:  45nMAssay Description:Binding constant for CSF1R kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM4851(cid_151194 | PTK787 | CHEMBL101253 | N-(4-chloroph...)
Affinity DataIC50: 54nMAssay Description:Inhibitory activity against VEGFR-2 using 2 uM ATP by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM4851(cid_151194 | PTK787 | CHEMBL101253 | N-(4-chloroph...)
Affinity DataIC50: 54nMpH: 7.5 T: 2°CAssay Description:The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/29/2006
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM4851(cid_151194 | PTK787 | CHEMBL101253 | N-(4-chloroph...)
Affinity DataIC50: 54nMAssay Description:Inhibition of VEGFR2 assessed as blockade of pGAT-biotin phosphorylation in presence of 2 uM ATP by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM4851(cid_151194 | PTK787 | CHEMBL101253 | N-(4-chloroph...)
Affinity DataIC50: 54nMAssay Description:Inhibition of VEGFR2 by enzymatic assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM4851(cid_151194 | PTK787 | CHEMBL101253 | N-(4-chloroph...)
Affinity DataIC50: 54nMAssay Description:Inhibition of VEGFR2 by HTRF assay in presence of 2 uM ATPMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM4851(cid_151194 | PTK787 | CHEMBL101253 | N-(4-chloroph...)
Affinity DataIC50: 54nMT: 2°CAssay Description:In a representative synthetic procedure (compound 3), a mixture of 1 (330 mg, 2 mM) and 3-F3C-C6H4-NHNH2 (370 mg, 2.1 mM) in anisole (20 mL) was stir...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/10/2012
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 1(Human)
Ambit Biosciences

Curated by ChEMBL
LigandPNGBDBM4851(cid_151194 | PTK787 | CHEMBL101253 | N-(4-chloroph...)
Affinity DataIC50: 54nMAssay Description:Inhibition of VEGFR1 by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM4851(cid_151194 | PTK787 | CHEMBL101253 | N-(4-chloroph...)
Affinity DataIC50: 55nMAssay Description:Inhibition of human recombinant GST-fused VEGFR2 kinase domain transphosphorylation expressed in baculovirus expression system using poly-Glu-Tyr (4:...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
TargetPlatelet-derived growth factor receptor beta(Human)
Ambit Biosciences

Curated by PubChem BioAssay
LigandPNGBDBM4851(cid_151194 | PTK787 | CHEMBL101253 | N-(4-chloroph...)
Affinity DataKd:  58nMAssay Description:Average Binding Constant for PDGFRB; NA=Not Active at 10 uMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM4851(cid_151194 | PTK787 | CHEMBL101253 | N-(4-chloroph...)
Affinity DataKd:  62nMAssay Description:Binding constant for VEGFR2 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/25/2012
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM4851(cid_151194 | PTK787 | CHEMBL101253 | N-(4-chloroph...)
Affinity DataKd:  62nMAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2011
Entry Details
PCBioAssay
TargetVascular endothelial growth factor receptor 2(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM4851(cid_151194 | PTK787 | CHEMBL101253 | N-(4-chloroph...)
Affinity DataKd:  62nMAssay Description:Binding constant for VEGFR2 kinase domainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/19/2012
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM4851(cid_151194 | PTK787 | CHEMBL101253 | N-(4-chloroph...)
Affinity DataIC50: 63nMAssay Description:In vitro inhibition of KDRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 3(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM4851(cid_151194 | PTK787 | CHEMBL101253 | N-(4-chloroph...)
Affinity DataIC50: 64nMAssay Description:Inhibition of human recombinant GST-fused VEGFR3 kinase domain transphosphorylation expressed in baculovirus expression system using poly-Glu-Tyr (4:...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/22/2024
Entry Details
PubMed
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