Found 19 Enz. Inhib. hit(s) with Target = 'Vascular endothelial growth factor receptor 1' and Ligand = 'BDBM4851'
TargetVascular endothelial growth factor receptor 1(Homo sapiens (Human))
Chemical Diversity
Curated by ChEMBL
Chemical Diversity
Curated by ChEMBL
Affinity DataIC50: 54nMAssay Description:Inhibition of VEGFR1 by HTRF assayMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 1(Homo sapiens (Human))
Chemical Diversity
Curated by ChEMBL
Chemical Diversity
Curated by ChEMBL
Affinity DataIC50: 77nMpH: 7.5 T: 2°CAssay Description:The in vitro kinase assays were performed in 96-well plates using the recombinant GST-fused kinase domains expressed in baculovirus and purified over...More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 1(Homo sapiens (Human))
Chemical Diversity
Curated by ChEMBL
Chemical Diversity
Curated by ChEMBL
Affinity DataIC50: 77nMAssay Description:Inhibition of human recombinant GST-fused VEGFR1 kinase domain transphosphorylation expressed in baculovirus expression system using poly-Glu-Tyr (4:...More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 1(Homo sapiens (Human))
Chemical Diversity
Curated by ChEMBL
Chemical Diversity
Curated by ChEMBL
Affinity DataIC50: 77nMAssay Description:Inhibition of vascular endothelial growth factor receptor 1More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 1(Homo sapiens (Human))
Chemical Diversity
Curated by ChEMBL
Chemical Diversity
Curated by ChEMBL
Affinity DataIC50: <100nMAssay Description:Inhibition of VEGFR1 (unknown origin)More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 1(Homo sapiens (Human))
Chemical Diversity
Curated by ChEMBL
Chemical Diversity
Curated by ChEMBL
Affinity DataIC50: 110nMAssay Description:In vitro inhibition of Vascular endothelial growth factor receptor 1 (VEGFR-1) expressed in baculovirusMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 1(Homo sapiens (Human))
Chemical Diversity
Curated by ChEMBL
Chemical Diversity
Curated by ChEMBL
TargetVascular endothelial growth factor receptor 1(Homo sapiens (Human))
Chemical Diversity
Curated by ChEMBL
Chemical Diversity
Curated by ChEMBL
Affinity DataIC50: 110nMAssay Description:Inhibition of VEGFR1 (unknown origin) by HTRF assay in presence of 8 uM ATPMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 1(Homo sapiens (Human))
Chemical Diversity
Curated by ChEMBL
Chemical Diversity
Curated by ChEMBL
Affinity DataIC50: 110nMAssay Description:Inhibition of VEGFR1 (unknown origin) assessed as blockade of pGAT-biotin phosphorylation in presence of 8 uM ATP by HTRF assayMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 1(Homo sapiens (Human))
Chemical Diversity
Curated by ChEMBL
Chemical Diversity
Curated by ChEMBL
Affinity DataIC50: 140nMAssay Description:Inhibition of VEGFR1 (unknown origin) assessed as blockade of pGAT-biotin phosphorylation in presence of 2 uM ATP by HTRF assayMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 1(Homo sapiens (Human))
Chemical Diversity
Curated by ChEMBL
Chemical Diversity
Curated by ChEMBL
Affinity DataIC50: 140nMAssay Description:Inhibition of VEGFR1 (unknown origin) by HTRF assayMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 1(Homo sapiens (Human))
Chemical Diversity
Curated by ChEMBL
Chemical Diversity
Curated by ChEMBL
Affinity DataIC50: 140nMAssay Description:Inhibition of VEGFR1 by enzymatic assayMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 1(Homo sapiens (Human))
Chemical Diversity
Curated by ChEMBL
Chemical Diversity
Curated by ChEMBL
Affinity DataIC50: 140nMAssay Description:Inhibitory activity against VEGFR-1 using 2 uM ATP by HTRF assayMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 1(Homo sapiens (Human))
Chemical Diversity
Curated by ChEMBL
Chemical Diversity
Curated by ChEMBL
Affinity DataIC50: 140nMpH: 7.5 T: 2°CAssay Description:In a representative synthetic procedure (compound 3), a mixture of 1 (330 mg, 2 mM) and 3-F3C-C6H4-NHNH2 (370 mg, 2.1 mM) in anisole (20 mL) was stir...More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 1(Homo sapiens (Human))
Chemical Diversity
Curated by ChEMBL
Chemical Diversity
Curated by ChEMBL
Affinity DataIC50: 140nMAssay Description:The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 1(Homo sapiens (Human))
Chemical Diversity
Curated by ChEMBL
Chemical Diversity
Curated by ChEMBL
Affinity DataIC50: 380nMAssay Description:Inhibition of VEGFR1 (unknown origin)More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 1(Homo sapiens (Human))
Chemical Diversity
Curated by ChEMBL
Chemical Diversity
Curated by ChEMBL
Affinity DataKd: 9.60nMAssay Description:Binding constant for FLT1 kinase domainMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 1(Homo sapiens (Human))
Chemical Diversity
Curated by ChEMBL
Chemical Diversity
Curated by ChEMBL
Affinity DataKd: 9.60nMpH: 7.4 T: 2°CAssay Description:Kinase inhibitors are a new class of therapeutics with a propensity to inhibit multiple targets. The biological consequences of multi-kinase activity...More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 1(Homo sapiens (Human))
Chemical Diversity
Curated by ChEMBL
Chemical Diversity
Curated by ChEMBL
Affinity DataKd: 9.60nMAssay Description:Binding constant for FLT1 kinase domainMore data for this Ligand-Target Pair