BDBM485655 US10940139, Example 02555::US11000515, Compound TABLE 7.106::US11213515, TABLE 7.106::US11541041, Compound Table 7.85

SMILES Cc1cccc(OCC(=O)Nc2nnc([nH]2)-c2ccccn2)c1

InChI Key InChIKey=KERLVTJVYMHOLQ-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 485655   

TargetGTPase KRas [G12D](Homo sapiens (Human))
Shy Therapeutics

US Patent
LigandPNGBDBM485655(US10940139, Example 02555 | US11000515, Compound T...)
Affinity DataIC50:  7.50E+3nMAssay Description:Buffer-I: 50 mM Tris, pH 7.5 150 mM NaCl (optional) 1 mM MgCl2 1 mM DTT. KRas G12D mutant protein was expressed as...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGTPase KRas [G12D,Q61H](Homo sapiens (Human))
Shy Therapeutics

US Patent
LigandPNGBDBM485655(US10940139, Example 02555 | US11000515, Compound T...)
Affinity DataIC50:  7.50E+3nMAssay Description:The following method was developed as specific assay for KRas G12D mutant protein.Buffer-I:50 mM Tris, pH 7.5150 mM NaCl (optional)1 mM MgCl21 mM DTT...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGTPase KRas [G12D,Q61H](Homo sapiens (Human))
Shy Therapeutics

US Patent
LigandPNGBDBM485655(US10940139, Example 02555 | US11000515, Compound T...)
Affinity DataIC50:  7.50E+3nMAssay Description:The following method was developed as specific assay for KRas G12D mutant protein.Buffer-I: 50 mM Tris, pH 7.5 150 mM NaCl (optional) ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGTPase KRas [G12D,Q61H](Homo sapiens (Human))
Shy Therapeutics

US Patent
LigandPNGBDBM485655(US10940139, Example 02555 | US11000515, Compound T...)
Affinity DataIC50:  7.50E+3nMAssay Description:Buffer-I: 50 mM Tris, pH 7.5 150 mM NaCl (optional) 1 mM MgCl2 1 mM DTT. KRas G12D mutant protein was expressed as...More data for this Ligand-Target Pair
In DepthDetails US Patent