BDBM488093 3-((4-(2-((4- (Piperazin-1- yl)phenyl)amino) pyrimidin-4-yl)-3-(pyridin- 3-yl)-1H-pyrazol-1- yl)methyl)benzonitrile::US10954216, Example 156

SMILES N#Cc1cccc(Cn2cc(c(n2)-c2cccnc2)-c2ccnc(Nc3ccc(cc3)N3CCNCC3)n2)c1

InChI Key InChIKey=KLEUCXDEXNSEGN-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 488093   

TargetActivin receptor type-1(Homo sapiens (Human))
Riken

US Patent
LigandPNGBDBM488093(3-((4-(2-((4- (Piperazin-1- yl)phenyl)amino) pyrim...)
Affinity DataIC50:  6.10nMAssay Description:TABLE 5: An overview of evaluation of an inhibitory effect of a compound of the present invention with respect to ALK2 is as follows. In a buffer sol...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetActivin receptor type-1 [R206H](Homo sapiens (Human))
Riken

US Patent
LigandPNGBDBM488093(3-((4-(2-((4- (Piperazin-1- yl)phenyl)amino) pyrim...)
Affinity DataIC50:  5.40nMAssay Description:R206H: An overview of evaluation of an inhibitory effect of a compound of the present invention with respect to ALK2 (R206H) is as follows.In a buffe...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent