BDBM488104 N-(4-(4-Amino-4- ethylpiperidin-1- yl)phenyl)-4-(1-ethyl- 3-(pyridin-3-yl)-1H- pyrazol-4- yl)pyrimidin-2-amine::US10954216, Example 177

SMILES CCn1cc(c(n1)-c1cccnc1)-c1ccnc(Nc2ccc(cc2)N2CCC(N)(CC)CC2)n1

InChI Key InChIKey=HBALAPRVSOJBQZ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 488104   

TargetActivin receptor type-1(Homo sapiens (Human))
Riken

US Patent
LigandPNGBDBM488104(N-(4-(4-Amino-4- ethylpiperidin-1- yl)phenyl)-4-(1...)
Affinity DataIC50:  3.5nMAssay Description:TABLE 5: An overview of evaluation of an inhibitory effect of a compound of the present invention with respect to ALK2 is as follows. In a buffer sol...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetActivin receptor type-1 [R206H](Homo sapiens (Human))
Riken

US Patent
LigandPNGBDBM488104(N-(4-(4-Amino-4- ethylpiperidin-1- yl)phenyl)-4-(1...)
Affinity DataIC50:  3nMAssay Description:R206H: An overview of evaluation of an inhibitory effect of a compound of the present invention with respect to ALK2 (R206H) is as follows.In a buffe...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent