BDBM488428 2-{4-Amino-1-tert-butyl-1H-pyrazolo[3,4- d]pyrimidin-3-yl}-3-chloro-1H-indole-6- carboxamide::US10954241, Example 68::US11548896, Example 68

SMILES CC(C)(C)n1nc(-c2[nH]c3cc(ccc3c2Cl)C(N)=O)c2c(N)ncnc12

InChI Key InChIKey=NHUUNNWREIOKFG-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 488428   

TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
Cancer Research Technology

US Patent
LigandPNGBDBM488428(2-{4-Amino-1-tert-butyl-1H-pyrazolo[3,4- d]pyrimid...)
Affinity DataIC50:  14.2nMAssay Description:Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed in 384-well w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProto-oncogene tyrosine-protein kinase receptor Ret [V804M](Homo sapiens (Human))
Cancer Research Technology

US Patent
LigandPNGBDBM488428(2-{4-Amino-1-tert-butyl-1H-pyrazolo[3,4- d]pyrimid...)
Affinity DataIC50:  35.1nMAssay Description:RET, RETV804M and KDR: Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
Cancer Research Technology

US Patent
LigandPNGBDBM488428(2-{4-Amino-1-tert-butyl-1H-pyrazolo[3,4- d]pyrimid...)
Affinity DataIC50:  14.2nMAssay Description:RET, RETV804M and KDR: Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProto-oncogene tyrosine-protein kinase receptor Ret [V804M](Homo sapiens (Human))
Cancer Research Technology

US Patent
LigandPNGBDBM488428(2-{4-Amino-1-tert-butyl-1H-pyrazolo[3,4- d]pyrimid...)
Affinity DataIC50:  35.1nMAssay Description:Kinase activity was detected using CisBio HTRF kinEASE kit based on time-resolved fluorescence transfer (FRET). The assay was performed in 384-well w...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent