BDBM489104 2-(5- (cyclopropylmethyl)- 3-(3- (phenylamino)phenyl)- 4-(4- sulfamoylbenzyl)- 1H-pyrazol-1- yl)thiazole-4- carboxylic acid;::US10961200, Compound 485::US11247971, Cmpd ID 485
SMILES NS(=O)(=O)c1ccc(Cc2c(CC3CC3)n(nc2-c2cccc(Nc3ccccc3)c2)-c2nc(cs2)C(O)=O)cc1
InChI Key InChIKey=QYIDJRLVIHGDJX-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 6 hits for monomerid = 489104
TargetL-lactate dehydrogenase A chain(Homo sapiens (Human))
The United States of America, As Represented By The Secretary, Department of Health and Human Services
US Patent
The United States of America, As Represented By The Secretary, Department of Health and Human Services
US Patent
Affinity DataIC50: <100nMAssay Description:Test compounds were placed in a Greiner Bio-One (Monroe, N.C.) 1536-well black solid bottom assay plate. 200 millimolar (mM) Tris HCl, pH 7.4, 100 mi...More data for this Ligand-Target Pair
TargetL-lactate dehydrogenase A chain(Homo sapiens (Human))
The United States of America, As Represented By The Secretary, Department of Health and Human Services
US Patent
The United States of America, As Represented By The Secretary, Department of Health and Human Services
US Patent
Affinity DataIC50: 314nMAssay Description:Inhibition of recombinant human LDHA using sodium pyruvate as substrate preincubated for 5 mins followed by diaphorase/resazurin addition and measure...More data for this Ligand-Target Pair
TargetL-lactate dehydrogenase A chain(Homo sapiens (Human))
The United States of America, As Represented By The Secretary, Department of Health and Human Services
US Patent
The United States of America, As Represented By The Secretary, Department of Health and Human Services
US Patent
Affinity DataKd: 1.5nMAssay Description:Binding affinity to LDHA (unknown origin) by SPR analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of recombinant human LDHB using sodium pyruvate as substrate preincubated for 5 mins followed by diaphorase/resazurin addition and measure...More data for this Ligand-Target Pair
TargetL-lactate dehydrogenase A chain(Homo sapiens (Human))
The United States of America, As Represented By The Secretary, Department of Health and Human Services
US Patent
The United States of America, As Represented By The Secretary, Department of Health and Human Services
US Patent
Affinity DataIC50: 3.10E+3nMAssay Description:Inhibition of LDHA in human A673 cells assessed as reduction in lactate production incubated for 2 hrs by fluorescence based assayMore data for this Ligand-Target Pair
TargetL-lactate dehydrogenase A chain(Homo sapiens (Human))
The United States of America, As Represented By The Secretary, Department of Health and Human Services
US Patent
The United States of America, As Represented By The Secretary, Department of Health and Human Services
US Patent
Affinity DataIC50: 6.70E+3nMAssay Description:Inhibition of LDHA in human MIA PaCa2 cells assessed as reduction in lactate production incubated for 2 hrs by fluorescence based assayMore data for this Ligand-Target Pair