BDBM489247 2-[(1S)-1-Cyclopropylethyl]-N-methyl-6-(4-methyl-2-{[6-(3-oxomorpholin-4-yl)pyridin-2-yl]amino}-1,3-thiazol-5-yl)-3-oxo-2,3-dihydro-1H-isoindole-4-sulfonamide::US10961236, Example 20

SMILES CNS(=O)(=O)c1cc(cc2CN([C@@H](C)C3CC3)C(=O)c12)-c1sc(Nc2cccc(n2)N2CCOCC2=O)nc1C

InChI Key InChIKey=FZLQVDKBOUEZHS-INIZCTEOSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 489247   

LigandPNGBDBM489247(2-[(1S)-1-Cyclopropylethyl]-N-methyl-6-(4-methyl-2...)
Affinity DataIC50:  0.700nMAssay Description:The activity of recombinant human PI3Kγ ((aa144-1102)-6His) and PI3Kα, β, δ (6-His(p110-p85α)) was determined by measuring t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM489247(2-[(1S)-1-Cyclopropylethyl]-N-methyl-6-(4-methyl-2...)
Affinity DataIC50:  0.900nMAssay Description:The activity of recombinant human PI3Kγ ((aa144-1102)-6His) and PI3Kα, β, δ (6-His(p110-p85α)) was determined by measuring t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM489247(2-[(1S)-1-Cyclopropylethyl]-N-methyl-6-(4-methyl-2...)
Affinity DataIC50:  37nMAssay Description:The activity of recombinant human PI3Kγ ((aa144-1102)-6His) and PI3Kα, β, δ (6-His(p110-p85α)) was determined by measuring t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM489247(2-[(1S)-1-Cyclopropylethyl]-N-methyl-6-(4-methyl-2...)
Affinity DataIC50:  40nMAssay Description:Inhibition of recombinant human PI3Kalpha assessed as reduction in ADP production using Dic8-PIP2 as substrate pre-treated for 15 mins followed by su...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM489247(2-[(1S)-1-Cyclopropylethyl]-N-methyl-6-(4-methyl-2...)
Affinity DataIC50:  0.631nMAssay Description:Inhibition of recombinant human PI3Kdelta assessed as reduction in ADP production using Dic8-PIP2 as substrate pre-treated for 15 mins followed by su...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM489247(2-[(1S)-1-Cyclopropylethyl]-N-methyl-6-(4-methyl-2...)
Affinity DataIC50:  0.794nMAssay Description:Inhibition of PI3Kgamma in C5a-stimulated mouse RAW 264 cells assessed as inhibition of AKT phosphorylation at Ser473 residue Pretreated for 15 mins ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM489247(2-[(1S)-1-Cyclopropylethyl]-N-methyl-6-(4-methyl-2...)
Affinity DataIC50:  4nMAssay Description:Inhibition of PI3Kdelta in anti-IgM-stimulated human JeKo-1 cells assessed as inhibition of AKT phosphorylation at Ser473 residue incubated for 60 mi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM489247(2-[(1S)-1-Cyclopropylethyl]-N-methyl-6-(4-methyl-2...)
Affinity DataIC50:  543nMAssay Description:The activity of recombinant human PI3Kγ ((aa144-1102)-6His) and PI3Kα, β, δ (6-His(p110-p85α)) was determined by measuring t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent