BDBM489289 2-[(2S)-Butan-2-yl]-N-methyl-6-(4-methyl-2-{[6-(3-oxomorpholin-4-yl)pyridin-2-yl]amino}-1,3-thiazol-5-yl)-3-oxo-2,3-dihydro-1H-isoindole-4-sulfonamide::US10961236, Example 62

SMILES CC[C@H](C)N1Cc2cc(cc(c2C1=O)S(=O)(=O)NC)-c1sc(Nc2cccc(n2)N2CCOCC2=O)nc1C

InChI Key InChIKey=NDSSKUUMDINTDG-HNNXBMFYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 489289   

LigandPNGBDBM489289(2-[(2S)-Butan-2-yl]-N-methyl-6-(4-methyl-2-{[6-(3-...)
Affinity DataIC50:  2.10nMAssay Description:The activity of recombinant human PI3Kγ ((aa144-1102)-6His) and PI3Kα, β, δ (6-His(p110-p85α)) was determined by measuring t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM489289(2-[(2S)-Butan-2-yl]-N-methyl-6-(4-methyl-2-{[6-(3-...)
Affinity DataIC50:  1.15E+3nMAssay Description:The activity of recombinant human PI3Kγ ((aa144-1102)-6His) and PI3Kα, β, δ (6-His(p110-p85α)) was determined by measuring t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM489289(2-[(2S)-Butan-2-yl]-N-methyl-6-(4-methyl-2-{[6-(3-...)
Affinity DataIC50:  162nMAssay Description:The activity of recombinant human PI3Kγ ((aa144-1102)-6His) and PI3Kα, β, δ (6-His(p110-p85α)) was determined by measuring t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM489289(2-[(2S)-Butan-2-yl]-N-methyl-6-(4-methyl-2-{[6-(3-...)
Affinity DataIC50:  0.800nMAssay Description:The activity of recombinant human PI3Kγ ((aa144-1102)-6His) and PI3Kα, β, δ (6-His(p110-p85α)) was determined by measuring t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent