BDBM489325 3-(benzo[d]thiazol-2-yl)-5-(4-(methylsulfonyl)phenyl)pyrazin-2-amine ::BDBM50341757::US10961232, Compound I-146

SMILES CS(=O)(=O)c1ccc(cc1)-c1cnc(N)c(n1)C1=[S]c2ccccc2N1

InChI Key InChIKey=LBFRVTYJRMMGTH-UHFFFAOYSA-N

Data  2 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 489325   

TargetSerine/threonine-protein kinase ATR(Homo sapiens (Human))
Vertex Pharmaceuticals

US Patent
LigandPNGBDBM489325(3-(benzo[d]thiazol-2-yl)-5-(4-(methylsulfonyl)phen...)
Affinity DataKi:  55nMAssay Description:Compounds were screened for their ability to inhibit ATR kinase using a radioactive-phosphate incorporation assay. Assays were carried out in a mixtu...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetSerine/threonine-protein kinase ATR(Homo sapiens (Human))
Vertex Pharmaceuticals

US Patent
LigandPNGBDBM489325(3-(benzo[d]thiazol-2-yl)-5-(4-(methylsulfonyl)phen...)
Affinity DataKi:  55nMAssay Description:Compounds were screened for their ability to inhibit ATR kinase using a radioactive-phosphate incorporation assay. Assays were carried out in a mixtu...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetSerine/threonine-protein kinase ATR(Homo sapiens (Human))
Vertex Pharmaceuticals

US Patent
LigandPNGBDBM489325(3-(benzo[d]thiazol-2-yl)-5-(4-(methylsulfonyl)phen...)
Affinity DataIC50:  22nMAssay Description:Inhibition of full length recombinant ATR after 24 hrs by radiometric phosphate incorporation assayMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails ArticlePubMed
TargetDNA-dependent protein kinase catalytic subunit(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM489325(3-(benzo[d]thiazol-2-yl)-5-(4-(methylsulfonyl)phen...)
Affinity DataIC50:  2.90E+3nMAssay Description:Inhibition of DNAPK after 2 hrs by radiometric phosphate incorporation assayMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails ArticlePubMed
TargetSerine-protein kinase ATM(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM489325(3-(benzo[d]thiazol-2-yl)-5-(4-(methylsulfonyl)phen...)
Affinity DataIC50:  720nMAssay Description:Inhibition of full length recombinant ATM after 24 hrs by radiometric phosphate incorporation assayMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails ArticlePubMed