BDBM490555 5-fluoro-N-(2-fluorophenyl)-4-(3-oxo[1,2,4]triazolo[4,3-a]pyridin-2(3H)-yl)-2-[(1S)-1-phenylethoxy]benzamide::US10968216, Example 223

SMILES C[C@H](Oc1cc(c(F)cc1C(=O)Nc1ccccc1F)-n1nc2ccccn2c1=O)c1ccccc1

InChI Key InChIKey=XZSPKXRQCLXYOC-KRWDZBQOSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 490555   

TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM490555(5-fluoro-N-(2-fluorophenyl)-4-(3-oxo[1,2,4]triazol...)
Affinity DataIC50:  3.80nMAssay Description:Assay—2: The enzymatic assay couples DHODH activity with bleaching of the dye 2,6-Dichlorophenolindophenol (DCIP) (Knecht and Loffler, 1998; Miller e...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Bayer Aktiengesellschaft

US Patent
LigandPNGBDBM490555(5-fluoro-N-(2-fluorophenyl)-4-(3-oxo[1,2,4]triazol...)
Affinity DataIC50:  4.50E+3nMAssay Description:Assay—1: The enzymatic assay couples DHODH activity with bleaching of the dye 2,6-dichlorophenolindophenol (DCIP) (Knecht and Loffler, 1998; Miller e...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent