BDBM492894 N-((6-amino-2- methylpyridin-3- yl)methyl)-2-(3- (methylsulfonyl)-4-((2- oxopyridin-1(2H)- yl)methyl)benzyl) isonicotinamide::US10981893, Example 23

SMILES Cc1cc(Cc2cc(ccn2)C(=O)NCc2ccc(N)nc2C)ccc1Cn1ccccc1=O

InChI Key InChIKey=KNKZRHCMHYDKGI-UHFFFAOYSA-N

Data  1 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 492894   

TargetPlasma kallikrein(Homo sapiens (Human))
Attune Pharmaceuticals

US Patent
LigandPNGBDBM492894(N-((6-amino-2- methylpyridin-3- yl)methyl)-2-(3- (...)
Affinity DataEC50: <100nMAssay Description:All dilutions were prepared in an assay buffer comprising 50 mM Tris-HCl pH 7.2, 150 mM NaCl, and 0.01% Triton X-100.Four fold serial dilutions were ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPlasma kallikrein(Homo sapiens (Human))
Attune Pharmaceuticals

US Patent
LigandPNGBDBM492894(N-((6-amino-2- methylpyridin-3- yl)methyl)-2-(3- (...)
Affinity DataIC50: <100nMAssay Description:The ability of the compounds disclosed herein to inhibit human plasma kallikrein activity was quantified according to the procedures below.A 10 mM so...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent