BDBM493629 US10988445, Example 309
SMILES CNS(=O)(=O)c1ccc2C(N(Cc2c1)C(=O)C1CCO1)C(=O)Nc1ccc(cc1)C(O)(C(F)(F)F)C(F)(F)F
InChI Key InChIKey=UMGNIRMNYZUZHY-UHFFFAOYSA-N
Data 5 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 5 hits for monomerid = 493629
Affinity DataIC50: 126nMAssay Description:The scintillation proximity assay (SPA) was run in white polystyrene flat-bottom 384-well plates (Greiner, cat. No. 781075). Assays were carried out ...More data for this Ligand-Target Pair
Affinity DataIC50: 50.1nMAssay Description:The assay was run in black 384 well plates (Greiner cat no: 784900). Various concentrations of test ligands in 0.1 microlitres DMSO were dispensed to...More data for this Ligand-Target Pair
Affinity DataIC50: 3.30E+3nMAssay Description:Inhibition of CYP2D6 in human liver microsomesMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Astrazeneca
Curated by ChEMBL
Astrazeneca
Curated by ChEMBL
Affinity DataIC50: >3.30E+4nMAssay Description:Inhibition of human ERGMore data for this Ligand-Target Pair
Affinity DataIC50: 128nMAssay Description:Inverse agonist activity at human RORC2 assessed as inhibition of SRC1-derived coactivator peptide by TR-FRET assayMore data for this Ligand-Target Pair