BDBM496902 CVD-0018409::PF-07321332::US11351149, Example 13::US11753373, Compound D-1-d::US20230391736, Example PF-07321332::WO2021250648, Example 13::science.abl4784, 6

SMILES CC(C)(C)[C@H](NC(=O)C(F)(F)F)C(=O)N1C[C@H]2[C@@H]([C@H]1C(=O)N[C@@H](C[C@@H]1CCNC1=O)C#N)C2(C)C

InChI Key InChIKey=LIENCHBZNNMNKG-OJFNHCPVSA-N

Data  10 KI  15 IC50  3 EC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 496902   

TargetReplicase polyprotein 1ab(2019-nCoV)
Texas A&M University

Curated by ChEMBL
LigandPNGBDBM496902(CVD-0018409 | PF-07321332 | US11351149, Example 13...)
Affinity DataKi:  3.10nMAssay Description:Binding affinity to SARS CoV-2 main protease by FRET assayMore data for this Ligand-Target Pair
TargetReplicase polyprotein 1ab(2019-nCoV)
Texas A&M University

Curated by ChEMBL
LigandPNGBDBM496902(CVD-0018409 | PF-07321332 | US11351149, Example 13...)
Affinity DataEC50:  3.40E+3nMAssay Description:Inhibition of eGFP fused SARS-CoV2 main protease transfected in HEK293T/17 cells incubated for 72 hrs by fluorescence based flow cytometry analysisMore data for this Ligand-Target Pair
TargetReplicase polyprotein 1ab(2019-nCoV)
Texas A&M University

Curated by ChEMBL
LigandPNGBDBM496902(CVD-0018409 | PF-07321332 | US11351149, Example 13...)
Affinity DataIC50:  66nMAssay Description:Inhibition of His/SUMO tagged SARS-CoV2 main protease expressed in Escherichia coli BL21 (DE3) cells using DABCYL-Lys-Thr-Ser-Ala-Val-Leu-Gln-Ser-Gly...More data for this Ligand-Target Pair