BDBM50002218 2-(1-Cyclopropylmethyl-piperidin-4-yl)-1-(4-fluoro-phenyl)-ethanone; hydrobromide::CHEMBL42228::CHEMBL543412

SMILES Fc1ccc(cc1)C(=O)CC1CCN(CC2CC2)CC1

InChI Key InChIKey=KWRMWQDKOGFMKP-UHFFFAOYSA-N

Data  7 KI  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 14 hits for monomerid = 50002218   

TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50002218(2-(1-Cyclopropylmethyl-piperidin-4-yl)-1-(4-fluoro...)
Affinity DataKi:  10nMAssay Description:Binding affinity for sigma receptor of guinea pig whole brain using [3H]-SKF- 100047 radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Mus musculus (Mouse))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50002218(2-(1-Cyclopropylmethyl-piperidin-4-yl)-1-(4-fluoro...)
Affinity DataKi:  10nMAssay Description:In vitro binding affinity for the mouse sigma opioid receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50002218(2-(1-Cyclopropylmethyl-piperidin-4-yl)-1-(4-fluoro...)
Affinity DataKi:  10nMAssay Description:Binding affinity against sigma receptor in bovine cerebellum using 2.0 nM [3H]- haloperidolMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A/2B/2C(Mus musculus (Mouse))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50002218(2-(1-Cyclopropylmethyl-piperidin-4-yl)-1-(4-fluoro...)
Affinity DataKi:  15nMAssay Description:In vitro binding affinity for serotonin 5-hydroxytryptamine (5-HT) 2 receptorsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(1A) dopamine receptor(Mus musculus (Mouse))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50002218(2-(1-Cyclopropylmethyl-piperidin-4-yl)-1-(4-fluoro...)
Affinity DataKi: >1.00E+3nMAssay Description:The compound was tested in vitro for its binding affinity towards dopamine receptor D1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(BOVINE)
New York University

Curated by ChEMBL
LigandPNGBDBM50002218(2-(1-Cyclopropylmethyl-piperidin-4-yl)-1-(4-fluoro...)
Affinity DataKi: >1.00E+3nMAssay Description:Binding affinity against Dopamine receptor D2 in bovine striatal homogenate using 200 pM [3H]- spiperone and 250 nM unlabeled ketanserinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50002218(2-(1-Cyclopropylmethyl-piperidin-4-yl)-1-(4-fluoro...)
Affinity DataKi:  1.63E+3nMAssay Description:Binding affinity for dopamine D2 receptor using [3H]spiperone in guinea pig striatumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50002218(2-(1-Cyclopropylmethyl-piperidin-4-yl)-1-(4-fluoro...)
Affinity DataIC50:  640nMAssay Description:Binding affinity towards Dopamine receptor D2 binding site using [3H]spiroperidol.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Rattus norvegicus (rat))
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50002218(2-(1-Cyclopropylmethyl-piperidin-4-yl)-1-(4-fluoro...)
Affinity DataIC50:  66nMAssay Description:Binding affinity towards 5-hydroxytryptamine 2A receptor binding site using [3H]ketanserin .More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50002218(2-(1-Cyclopropylmethyl-piperidin-4-yl)-1-(4-fluoro...)
Affinity DataIC50:  4.40E+4nMAssay Description:Binding affinity towards 5-hydroxytryptamine 1A receptor binding site using [3H]8-OH-DPAT .More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(RAT)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50002218(2-(1-Cyclopropylmethyl-piperidin-4-yl)-1-(4-fluoro...)
Affinity DataIC50:  2.60nMAssay Description:Compound was evaluated for the binding affinity towards Sigma receptor type 1 using radioligand ([3H]-(+)- Pentazocine) binding assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(RAT)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50002218(2-(1-Cyclopropylmethyl-piperidin-4-yl)-1-(4-fluoro...)
Affinity DataIC50:  23nMAssay Description:Binding affinity towards Sigma receptor site 2 in rat brain using [3H]DTG as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Mus musculus (Mouse))
Dupont Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50002218(2-(1-Cyclopropylmethyl-piperidin-4-yl)-1-(4-fluoro...)
Affinity DataIC50:  1.63E+3nMAssay Description:In vitro binding affinity towards dopamine receptor D2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(RAT)
H. Lundbeck

Curated by ChEMBL
LigandPNGBDBM50002218(2-(1-Cyclopropylmethyl-piperidin-4-yl)-1-(4-fluoro...)
Affinity DataIC50:  2.60nMAssay Description:Binding affinity towards sigma receptor binding site 1 using [3H](+)-pentazocineMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed