BDBM50003057 7-Amino-1,2,3-trimethyl-2,8-dihydro-2,5,6,8-tetraaza-cyclopenta[a]naphthalen-9-one::CHEMBL122959

SMILES Cc1n(C)c(C)c2c1cnc1nc(N)[nH]c(=O)c21

InChI Key InChIKey=WNAFKDMXNUMRHW-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50003057   

TargetDihydrofolate reductase(Homo sapiens (Human))
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50003057(7-Amino-1,2,3-trimethyl-2,8-dihydro-2,5,6,8-tetraa...)
Affinity DataIC50: >9.50E+4nMAssay Description:Compound was evaluated for the inhibition of recombinant human Dihydrofolate reductase (DHFR); no inhibitionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidylate synthase(Lactobacillus casei)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50003057(7-Amino-1,2,3-trimethyl-2,8-dihydro-2,5,6,8-tetraa...)
Affinity DataIC50:  9.50E+4nMAssay Description:Compound was evaluated for the inhibition of Lactobacillus casei thymidylate synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional purine biosynthesis protein ATIC(Homo sapiens (Human))
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50003057(7-Amino-1,2,3-trimethyl-2,8-dihydro-2,5,6,8-tetraa...)
Affinity DataIC50: >9.50E+4nMAssay Description:Compound was evaluated for the inhibition of Aminoimidazole carboxamide ribonucleotide formyl transferase (AICAR) with (6R) tetrahydrofolate as subst...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTrifunctional purine biosynthetic protein adenosine-3(Mus musculus)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50003057(7-Amino-1,2,3-trimethyl-2,8-dihydro-2,5,6,8-tetraa...)
Affinity DataIC50: >9.50E+4nMAssay Description:Compound was evaluated for the inhibition of Glycinamide ribonucleotide formyl transferase (GAR) with formyl (6R) tetrahydrofolate as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed