BDBM46858 1-methyl-3,6-dihydro-2H-pyridine-5-carboxylic acid methyl ester;hydrobromide::ARECOLINE::ARECOLINE HYDROBROMIDE::MLS000028840::SMR000058258::arecoline;hydrobromide::cid_9301::methyl 1-methyl-3,6-dihydro-2H-pyridine-5-carboxylate;hydrobromide
SMILES COC(=O)C1=CCCN(C)C1
InChI Key InChIKey=HJJPJSXJAXAIPN-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 92 hits for monomerid = 46858
TargetMuscarinic acetylcholine receptor M1/M2/M3/M4/M5(Rat)
Royal Danish School of Pharmacy
Curated by ChEMBL
Royal Danish School of Pharmacy
Curated by ChEMBL
Affinity DataIC50: 1.90nMAssay Description:Inhibition of [3H]oxotremorine-M binding to rat brain membrane Muscarinic acetylcholine receptorMore data for this Ligand-Target Pair
Affinity DataKi: 3.30nMAssay Description:Binding affinity (low) of [3H](R)-QNB binding to Muscarinic acetylcholine receptor M1 expressed in A9 L cell line in the absence of 300 uM GTP-gamma-...More data for this Ligand-Target Pair
Affinity DataKi: 5.5nMAssay Description:Binding affinity of [3H]-(R)-QNB binding to Muscarinic acetylcholine receptor M1 expressed in A9 L cell line in the presence of 300 uM GTP-gamma-SMore data for this Ligand-Target Pair
Affinity DataKi: 14nMAssay Description:Inhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M1 expressed in CHO cell membranesMore data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M1/M2/M3/M4/M5(Rat)
Royal Danish School of Pharmacy
Curated by ChEMBL
Royal Danish School of Pharmacy
Curated by ChEMBL
Affinity DataIC50: 20nMAssay Description:Ability to displace [3H]cis--2-methyl-5-((dimethylamino)methyl)-1,3-di oxolane from muscarinic acetylcholine receptor in rat cortical tissue.More data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M1/M2/M3/M4/M5(Rat)
Royal Danish School of Pharmacy
Curated by ChEMBL
Royal Danish School of Pharmacy
Curated by ChEMBL
Affinity DataIC50: 24nMAssay Description:Binding affinity against muscarinic receptor in rat brain membranes using oxotremorine-M as ligandMore data for this Ligand-Target Pair
Affinity DataEC50: 25nMAssay Description:In Vitro activity at the cloned Human Muscarinic acetylcholine receptor M2 determined by receptor selection and amplification technology (R-SAT).More data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M4(Human)
National Institute of Diabetes and Digestive and Kidney Diseases
Curated by ChEMBL
National Institute of Diabetes and Digestive and Kidney Diseases
Curated by ChEMBL
Affinity DataKi: 26nMAssay Description:Inhibition of [3H]- oxotremorine-M binding to human Muscarinic acetylcholine receptor M4 in CHO cell membranesMore data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M1/M2/M3/M4/M5(Rat)
Royal Danish School of Pharmacy
Curated by ChEMBL
Royal Danish School of Pharmacy
Curated by ChEMBL
Affinity DataKi: 40nMAssay Description:Binding affinity for muscarinic receptor site in rat hippocampus was determined using competitive radioligand binding assays employing [3H]OXO-MMore data for this Ligand-Target Pair
Affinity DataKi: 40nMAssay Description:Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine rece...More data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M2(Rat)
National Institute of Diabetes and Digestive and Kidney Diseases
Curated by ChEMBL
National Institute of Diabetes and Digestive and Kidney Diseases
Curated by ChEMBL
Affinity DataKi: 40nMAssay Description:Inhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M2 in rat cerebral cortical membranesMore data for this Ligand-Target Pair
Affinity DataKi: 40nMAssay Description:Inhibition of [3H]- quinuclidinyl benzilate binding to human Muscarinic acetylcholine receptor M2 expressed in CHO cell membraneMore data for this Ligand-Target Pair
Affinity DataKi: 40nMAssay Description:The binding affinity was measured as inhibition of binding of [3H]- oxotremorine-M m2 toMuscarinic acetylcholine receptor M2 in membranes of CHO cell...More data for this Ligand-Target Pair
Affinity DataEC50: 73nMAssay Description:Agonist activity at muscarinic acetylcholine receptor in isolated guinea pig ileum.More data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M1/M2/M3/M4/M5(Rat)
Royal Danish School of Pharmacy
Curated by ChEMBL
Royal Danish School of Pharmacy
Curated by ChEMBL
Affinity DataIC50: 77nMAssay Description:In vitro binding affinity to muscarinic acetylcholine receptor site in rat brain assayed using [3H]oxotremorine-M as the radioligand.More data for this Ligand-Target Pair
Affinity DataIC50: 77nMAssay Description:Binding activity against muscarinic acetylcholine receptor M1 in rat brain, using [3H]OXO-M as the radioligand.More data for this Ligand-Target Pair
Affinity DataIC50: 77nMAssay Description:Displacement of [3H]oxotremorine-M (Oxo-M) from rat hippocampus muscarinic acetylcholine receptor M1More data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M1/M2/M3/M4/M5(Rat)
Royal Danish School of Pharmacy
Curated by ChEMBL
Royal Danish School of Pharmacy
Curated by ChEMBL
Affinity DataIC50: 77nMAssay Description:Displacement of [3H]-OXO-M (oxotremorine-M) from the central muscarinic receptor sites of the rat brain membranesMore data for this Ligand-Target Pair
Affinity DataIC50: 77nMAssay Description:In vitro binding affinity against M1 receptor from rat hippocampus, using [3H]oxotremorine-M (Oxo-M) as radioligand.More data for this Ligand-Target Pair
Affinity DataEC50: 83nMAssay Description:In vitro binding affinity for muscarinic M1 receptor by displacing [3H]Pirenzepine binding on rat brain homogenateMore data for this Ligand-Target Pair
Affinity DataEC50: 100nMAssay Description:Contraction of guinea pig ileum by muscarinic AChR activation, which could be inhibited by application of atropineMore data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M1/M2/M3/M4/M5(Rat)
Royal Danish School of Pharmacy
Curated by ChEMBL
Royal Danish School of Pharmacy
Curated by ChEMBL
Affinity DataIC50: 115nMAssay Description:In vitro inhibition of [3H]OXO-M binding to Muscarinic receptor from rat cortical homogenatesMore data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M1/M2/M3/M4/M5(Rat)
Royal Danish School of Pharmacy
Curated by ChEMBL
Royal Danish School of Pharmacy
Curated by ChEMBL
Affinity DataIC50: 115nMAssay Description:In vitro ability to displace [3H]oxotremorine-M (OXO-M) from rat cerebral cortex Muscarinic acetylcholine receptorMore data for this Ligand-Target Pair
Affinity DataIC50: 115nMAssay Description:Ability to displace [3H]oxotremorine from Muscarinic acetylcholine receptor M1 expressed in CHO cells.More data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M1/M2/M3/M4/M5(Rat)
Royal Danish School of Pharmacy
Curated by ChEMBL
Royal Danish School of Pharmacy
Curated by ChEMBL
Affinity DataIC50: 120nMAssay Description:Compound was tested for its ability to inhibit muscarinic receptor in rat cerebral cortex using [3H]oxotremorine-M (OXO-M); Range is 75-170More data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M4(Human)
National Institute of Diabetes and Digestive and Kidney Diseases
Curated by ChEMBL
National Institute of Diabetes and Digestive and Kidney Diseases
Curated by ChEMBL
Affinity DataEC50: 130nMAssay Description:In Vitro activity at the cloned Human Muscarinic acetylcholine receptor M4 determined by receptor selection and amplification technology (R-SAT)More data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rat)
National Institute of Diabetes and Digestive and Kidney Diseases
Curated by ChEMBL
National Institute of Diabetes and Digestive and Kidney Diseases
Curated by ChEMBL
Affinity DataKi: 270nMAssay Description:Inhibition of binding of [3H]nicotine to Nicotinic acetylcholine receptor alpha4-beta2 in rat cerebral cortical membranes at 100 uM concentrationMore data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Rat)
National Institute of Diabetes and Digestive and Kidney Diseases
Curated by ChEMBL
National Institute of Diabetes and Digestive and Kidney Diseases
Curated by ChEMBL
Affinity DataKi: 270nMAssay Description:The compound was evaluated for percentage inhibition of binding of [3H]- nicotine to Nicotinic acetylcholine receptor alpha4-beta2 in Rat Cerebral Co...More data for this Ligand-Target Pair
Affinity DataEC50: 340nMAssay Description:In Vitro activity at the cloned Human Muscarinic acetylcholine receptor M3 determined by receptor selection and amplification technology (R-SAT)More data for this Ligand-Target Pair
Affinity DataIC50: 545nMAssay Description:Efficacy at muscarinic acetylcholine receptor M1 measured by the ability to inhibit the electrically stimulated twitch of the rabbit vas deferensMore data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M2(Rat)
National Institute of Diabetes and Digestive and Kidney Diseases
Curated by ChEMBL
National Institute of Diabetes and Digestive and Kidney Diseases
Curated by ChEMBL
Affinity DataIC50: 590nMAssay Description:Inhibition of [3H]quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M2 of rat heartMore data for this Ligand-Target Pair
Affinity DataEC50: 600nMAssay Description:In Vitro activity at the cloned Human Muscarinic acetylcholine receptor M5 determined by receptor selection and amplification technology (R-SAT)More data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M2(Rat)
National Institute of Diabetes and Digestive and Kidney Diseases
Curated by ChEMBL
National Institute of Diabetes and Digestive and Kidney Diseases
Curated by ChEMBL
TargetMuscarinic acetylcholine receptor M1/M2/M3/M4/M5(Rat)
Royal Danish School of Pharmacy
Curated by ChEMBL
Royal Danish School of Pharmacy
Curated by ChEMBL
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of [3H]-(R)-QNB binding to muscarinic receptors of rat brain membranes.More data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M1/M2/M3/M4/M5(Rat)
Royal Danish School of Pharmacy
Curated by ChEMBL
Royal Danish School of Pharmacy
Curated by ChEMBL
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of [3H](R)-QNB binding to muscarinic receptor in rat brain membranesMore data for this Ligand-Target Pair
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of [3H]pirenzepine binding to rat brain membrane Muscarinic acetylcholine receptor M1More data for this Ligand-Target Pair
Affinity DataIC50: 1.30E+3nMAssay Description:Displacement of [3H]-Pz (pirenzepine) from the muscarinic receptor M1 of the rat hippocampusMore data for this Ligand-Target Pair
Affinity DataIC50: 1.30E+3nMAssay Description:Displacement of [3H]pirenzepine (Pz) from rat hippocampus muscarinic acetylcholine receptor M1More data for this Ligand-Target Pair
Affinity DataIC50: 1.30E+3nMAssay Description:In vitro binding affinity against muscarinic acetylcholine receptor M1 from rat hippocampus, using [3H]pirenzepine (Pz) as radioligandMore data for this Ligand-Target Pair
Affinity DataIC50: 1.30E+3nMAssay Description:Binding activity against muscarinic acetylcholine receptor M1 in rat brain, using [3H]-Pz as the radioligand.More data for this Ligand-Target Pair
Affinity DataIC50: 1.74E+3nMAssay Description:Evaluated for inhibition of binding of [3H]pirenzepine to homogenized rat cerebral cortex membranesMore data for this Ligand-Target Pair
Affinity DataIC50: 1.74E+3nMAssay Description:Ability to displace [3H]pirenzepine (pir) from muscarinic acetylcholine receptor M1 in rat cortical tissue.More data for this Ligand-Target Pair
Affinity DataIC50: 1.80E+3nMAssay Description:In vitro affinity is evaluated, using quinuclidynyl benzylate (QNB) as radioligand in human cloned Muscarinic acetylcholine receptor M2More data for this Ligand-Target Pair
TargetMucolipin-3(Human)
The Scripps Research Institute Molecular Screening Center
Curated by PubChem BioAssay
The Scripps Research Institute Molecular Screening Center
Curated by PubChem BioAssay
Affinity DataEC50: 2.26E+3nMAssay Description:Source (MLPCN Center Name): The Scripps Research Institute Molecular Screening Center (SRIMSC) Center Affiliation: The Scripps Research Institute (TS...More data for this Ligand-Target Pair
Affinity DataKi: 2.40E+3nMAssay Description:Binding affinity of compound was determined towards human Muscarinic acetylcholine receptor M2 using [3H]QNB radioligandMore data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M4(Human)
National Institute of Diabetes and Digestive and Kidney Diseases
Curated by ChEMBL
National Institute of Diabetes and Digestive and Kidney Diseases
Curated by ChEMBL
Affinity DataKi: 2.40E+3nMAssay Description:Inhibition of binding of [3H]quinuclidinyl benzilate to muscarinic receptors in membranes of CHO cells transfected with Muscarinic acetylcholine rece...More data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M4(Rat)
National Institute of Diabetes and Digestive and Kidney Diseases
Curated by ChEMBL
National Institute of Diabetes and Digestive and Kidney Diseases
Curated by ChEMBL
Affinity DataKi: 2.40E+3nMAssay Description:Inhibition of binding of [3H]quinuclidinyl benzilate to Muscarinic acetylcholine receptor M4 in rat cerebral cortical membranesMore data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M4(Human)
National Institute of Diabetes and Digestive and Kidney Diseases
Curated by ChEMBL
National Institute of Diabetes and Digestive and Kidney Diseases
Curated by ChEMBL
Affinity DataKi: 2.40E+3nMAssay Description:Inhibition of [3H]- quinuclidinyl benzilate binding to Muscarinic acetylcholine receptor M4 expressed in CHO cell membranesMore data for this Ligand-Target Pair
Affinity DataKi: 2.46E+3nMAssay Description:Binding affinity to human cloned muscarinic M2 receptor expressed in CHO cellsMore data for this Ligand-Target Pair