BDBM50006806 C,C,C-Trifluoro-N-[3-(quinolin-2-ylmethoxy)-phenyl]-methanesulfonamide::C,C,C-Trifluoro-N-[3-(quinolin-2-ylmethoxy)-phenyl]-methanesulfonamide( Wy-48,252)::C,C,C-Trifluoro-N-[3-(quinolin-2-ylmethoxy)-phenyl]-methanesulfonamide(Wy 48252)::C,C,C-Trifluoro-N-[3-(quinolin-2-ylmethoxy)-phenyl]-methanesulfonamide(Wy-48,252)::CHEMBL17344::Ritolukast

SMILES FC(F)(F)S(=O)(=O)Nc1cccc(OCc2ccc3ccccc3n2)c1

InChI Key InChIKey=GOHUJGMYCZDYDF-UHFFFAOYSA-N

Data  2 KI  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50006806   

TargetCysteinyl leukotriene receptor 1(GUINEA PIG)
Rorer Central Research

Curated by ChEMBL
LigandPNGBDBM50006806(C,C,C-Trifluoro-N-[3-(quinolin-2-ylmethoxy)-phenyl...)
Affinity DataKi:  35nMAssay Description:Binding affinity against Cysteinyl leukotriene D4 receptor from guinea pig lung was determined using [3H]-LTD4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCysteinyl leukotriene receptor 1(GUINEA PIG)
Rorer Central Research

Curated by ChEMBL
LigandPNGBDBM50006806(C,C,C-Trifluoro-N-[3-(quinolin-2-ylmethoxy)-phenyl...)
Affinity DataKi:  35nMAssay Description:Compound was evaluated for its ability to displace [3H]-LTD4 from LTD4 receptor in guinea pig lung membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCysteinyl leukotriene receptor 1/2(Homo sapiens (Human))
Roche Research Center

Curated by ChEMBL
LigandPNGBDBM50006806(C,C,C-Trifluoro-N-[3-(quinolin-2-ylmethoxy)-phenyl...)
Affinity DataIC50:  6.00E+3nMAssay Description:Inhibitory activity to block binding of [3H]leukotriene D4 to LTD4 receptor sites in homogenized guinea pig lungMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1/2(RAT)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50006806(C,C,C-Trifluoro-N-[3-(quinolin-2-ylmethoxy)-phenyl...)
Affinity DataIC50:  9.10E+3nMAssay Description:Concentration for 50% inhibition of A-23187-stimulated radiolabeled 5-HETE and TXB2 synthesis by Prostaglandin G/H synthaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1/2(RAT)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50006806(C,C,C-Trifluoro-N-[3-(quinolin-2-ylmethoxy)-phenyl...)
Affinity DataIC50:  3.30E+3nMAssay Description:Inhibitory concentration to inhibit Prostaglandin G/H synthase in the ratMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rattus norvegicus)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50006806(C,C,C-Trifluoro-N-[3-(quinolin-2-ylmethoxy)-phenyl...)
Affinity DataIC50:  4.60E+3nMAssay Description:Inhibitory concentration of the compound to inhibit 5-lipoxygenase in the ratMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rattus norvegicus)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM50006806(C,C,C-Trifluoro-N-[3-(quinolin-2-ylmethoxy)-phenyl...)
Affinity DataIC50:  2.00E+3nMAssay Description:Concentration for 50% inhibition of A-23,187-stimulated radiolabelled 5-HETE and TXB2 synthesis by PMN 5-lipoxygenaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed