BDBM50007554 4-Methoxymethyl-6-propoxy-9H-beta-carboline-3-carboxylic acid ethyl ester::CHEMBL49141

SMILES CCCOc1ccc2[nH]c3cnc(C(=O)OCC)c(COC)c3c2c1

InChI Key InChIKey=WRXDVVALWQGPMW-UHFFFAOYSA-N

Data  15 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 15 hits for monomerid = 50007554   

TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-3/gamma-2(Homo sapiens (Human))
University Of Wisconsin-Milwaukee

Curated by ChEMBL
LigandPNGBDBM50007554(4-Methoxymethyl-6-propoxy-9H-beta-carboline-3-carb...)
Affinity DataKi:  0.490nMAssay Description:Binding affinity measured using LtK- cell membranes expressing GABA alpha1-beta3-gamma2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid receptor subunit alpha-1/beta-3/gamma-2(Homo sapiens (Human))
University Of Wisconsin-Milwaukee

Curated by ChEMBL
LigandPNGBDBM50007554(4-Methoxymethyl-6-propoxy-9H-beta-carboline-3-carb...)
Affinity DataKi:  0.490nMAssay Description:Binding affinity for human recombinant gamma-aminobutyric-acid (GABA) A receptor alpha-1-beta-3-gamma-2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50007554(4-Methoxymethyl-6-propoxy-9H-beta-carboline-3-carb...)
Affinity DataKi:  0.5nMAssay Description:Binding affinity to human recombinant GABAA alpha1 receptor assessed as inhibition constant incubated for 1 hrs by liquid scintillation counting anal...More data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM50007554(4-Methoxymethyl-6-propoxy-9H-beta-carboline-3-carb...)
Affinity DataKi:  1nMAssay Description:Binding affinity to human recombinant GABAA alpha2 receptor assessed as inhibition constant incubated for 1 hrs by liquid scintillation counting anal...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetGABA-A receptor; alpha-2/beta-3/gamma-2(Homo sapiens (Human))
University Of Wisconsin-Milwaukee

Curated by ChEMBL
LigandPNGBDBM50007554(4-Methoxymethyl-6-propoxy-9H-beta-carboline-3-carb...)
Affinity DataKi:  1.20nMAssay Description:Binding affinity to human recombinant gamma-aminobutyric-acid (GABA) A receptor alpha-2-beta-3-gamma-2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGABA-A receptor; alpha-2/beta-3/gamma-2(Homo sapiens (Human))
University Of Wisconsin-Milwaukee

Curated by ChEMBL
LigandPNGBDBM50007554(4-Methoxymethyl-6-propoxy-9H-beta-carboline-3-carb...)
Affinity DataKi:  1.21nMAssay Description:Binding affinity measured using LtK- cell membranes expressing GABA alpha2-beta3-gamma2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50007554(4-Methoxymethyl-6-propoxy-9H-beta-carboline-3-carb...)
Affinity DataKi:  2nMAssay Description:Binding affinity to human recombinant GABAA alpha5 receptor assessed as inhibition constant incubated for 1 hrs by liquid scintillation counting anal...More data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM50007554(4-Methoxymethyl-6-propoxy-9H-beta-carboline-3-carb...)
Affinity DataKi:  2nMAssay Description:Binding affinity to human recombinant GABAA alpha3 receptor assessed as inhibition constant incubated for 1 hrs by liquid scintillation counting anal...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-3/beta-3/gamma-2(Homo sapiens (Human))
University Of Wisconsin-Milwaukee

Curated by ChEMBL
LigandPNGBDBM50007554(4-Methoxymethyl-6-propoxy-9H-beta-carboline-3-carb...)
Affinity DataKi:  2.20nMAssay Description:Binding affinity for human recombinant gamma-aminobutyric-acid (GABA) A receptor alpha-3-beta-3-gamma-2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid receptor subunit alpha-3/beta-3/gamma-2(Homo sapiens (Human))
University Of Wisconsin-Milwaukee

Curated by ChEMBL
LigandPNGBDBM50007554(4-Methoxymethyl-6-propoxy-9H-beta-carboline-3-carb...)
Affinity DataKi:  2.20nMAssay Description:Binding affinity measured using LtK- cell membranes expressing GABA alpha3-beta3-gamma2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGABA-A receptor; alpha-5/beta-3/gamma-2(Homo sapiens (Human))
University Of Wisconsin-Milwaukee

Curated by ChEMBL
LigandPNGBDBM50007554(4-Methoxymethyl-6-propoxy-9H-beta-carboline-3-carb...)
Affinity DataKi:  2.40nMAssay Description:Binding affinity measured using LtK- cell membranes expressing Gamma-aminobutyric-acid A receptor alpha5-beta3-gamma2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGABA-A receptor; alpha-5/beta-3/gamma-2(Homo sapiens (Human))
University Of Wisconsin-Milwaukee

Curated by ChEMBL
LigandPNGBDBM50007554(4-Methoxymethyl-6-propoxy-9H-beta-carboline-3-carb...)
Affinity DataKi:  2.40nMAssay Description:Binding affinity for human recombinant gamma-aminobutyric-acid (GABA) A receptor alpha-5-beta-3-gamma-2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50007554(4-Methoxymethyl-6-propoxy-9H-beta-carboline-3-carb...)
Affinity DataKi:  1.30E+3nMAssay Description:Binding affinity to human recombinant GABAA alpha6 receptor assessed as inhibition constant incubated for 1 hrs by liquid scintillation counting anal...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetGamma-aminobutyric acid receptor subunit alpha-6/beta-3/gamma-2(Homo sapiens (Human))
University Of Wisconsin-Milwaukee

Curated by ChEMBL
LigandPNGBDBM50007554(4-Methoxymethyl-6-propoxy-9H-beta-carboline-3-carb...)
Affinity DataKi:  1.34E+3nMAssay Description:Binding affinity for human recombinant gamma-aminobutyric-acid (GABA) A receptor alpha-6-beta-3-gamma-2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGamma-aminobutyric acid receptor subunit alpha-6/beta-3/gamma-2(Homo sapiens (Human))
University Of Wisconsin-Milwaukee

Curated by ChEMBL
LigandPNGBDBM50007554(4-Methoxymethyl-6-propoxy-9H-beta-carboline-3-carb...)
Affinity DataKi:  1.34E+3nMAssay Description:Binding affinity measured using LtK- cell membranes expressing Gamma-aminobutyric-acid A receptor alpha6-beta3-gamma2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed