BDBM82071 CAS_93413-69-5::CAS_99300-78-4::NSC_62923::VENLAFAXINE::Venlafaxine hydrochloride::WY-45030::WY-45655

SMILES COc1ccc(cc1)C(CN(C)C)C1(O)CCCCC1

InChI Key InChIKey=PNVNVHUZROJLTJ-UHFFFAOYSA-N

Data  164 KI  58 IC50  4 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 226 hits for monomerid = 82071   

TargetSodium-dependent serotonin transporter(Rat)
Wyeth Laboratories

Curated by PDSP Ki Database
LigandPNGBDBM82071(NSC_62923 | WY-45030 | VENLAFAXINE | CAS_93413-69-...)
Affinity DataKi:  0.100nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2011
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Rat)
Wyeth Laboratories

Curated by PDSP Ki Database
LigandPNGBDBM82071(NSC_62923 | WY-45030 | VENLAFAXINE | CAS_93413-69-...)
Affinity DataKi:  0.190nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2011
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Rat)
Wyeth Laboratories

Curated by PDSP Ki Database
LigandPNGBDBM82071(NSC_62923 | WY-45030 | VENLAFAXINE | CAS_93413-69-...)
Affinity DataKi:  0.210nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2011
Entry Details Article
PubMed
TargetNorepinephrine transporter(Rat)
Wyeth Laboratories

Curated by PDSP Ki Database
LigandPNGBDBM82071(NSC_62923 | WY-45030 | VENLAFAXINE | CAS_93413-69-...)
Affinity DataKi:  0.640nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2011
Entry Details Article
PubMed
TargetNorepinephrine transporter(Rat)
Wyeth Laboratories

Curated by PDSP Ki Database
LigandPNGBDBM82071(NSC_62923 | WY-45030 | VENLAFAXINE | CAS_93413-69-...)
Affinity DataKi:  0.760nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2011
Entry Details Article
PubMed
TargetNorepinephrine transporter(Rat)
Wyeth Laboratories

Curated by PDSP Ki Database
LigandPNGBDBM82071(NSC_62923 | WY-45030 | VENLAFAXINE | CAS_93413-69-...)
Affinity DataKi:  1.26nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/11/2012
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Rat)
Wyeth Laboratories

Curated by PDSP Ki Database
LigandPNGBDBM82071(NSC_62923 | WY-45030 | VENLAFAXINE | CAS_93413-69-...)
Affinity DataKi:  2.80nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2011
Entry Details Article
PubMed
TargetNorepinephrine transporter(Rat)
Wyeth Laboratories

Curated by PDSP Ki Database
LigandPNGBDBM82071(NSC_62923 | WY-45030 | VENLAFAXINE | CAS_93413-69-...)
Affinity DataKi:  3.14nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2011
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Emory University

Curated by PDSP Ki Database
LigandPNGBDBM82071(NSC_62923 | WY-45030 | VENLAFAXINE | CAS_93413-69-...)
Affinity DataKi:  7.5nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/1/2012
Entry Details
PubMed
TargetSodium-dependent serotonin transporter(Human)
Emory University

Curated by PDSP Ki Database
LigandPNGBDBM82071(NSC_62923 | WY-45030 | VENLAFAXINE | CAS_93413-69-...)
Affinity DataKi:  7.80nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/29/2012
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Emory University

Curated by PDSP Ki Database
LigandPNGBDBM82071(NSC_62923 | WY-45030 | VENLAFAXINE | CAS_93413-69-...)
Affinity DataKi:  8.90nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/3/2012
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Emory University

Curated by PDSP Ki Database
LigandPNGBDBM82071(NSC_62923 | WY-45030 | VENLAFAXINE | CAS_93413-69-...)
Affinity DataKd:  8.90nMAssay Description:Equilibrium dissociation constant (KD) for Competitive binding between [3H]- imipramine and the compound at human transporter -hSERTMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/29/2012
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Rat)
Wyeth Laboratories

Curated by PDSP Ki Database
LigandPNGBDBM82071(NSC_62923 | WY-45030 | VENLAFAXINE | CAS_93413-69-...)
Affinity DataKi:  19nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/1/2012
Entry Details
PubMed
TargetSodium-dependent serotonin transporter(Human)
Emory University

Curated by PDSP Ki Database
LigandPNGBDBM82071(NSC_62923 | WY-45030 | VENLAFAXINE | CAS_93413-69-...)
Affinity DataIC50: 20nMAssay Description:Inhibition of human SERT expressed in HEK293 cells assessed as decrease in [3H]-serotonin reuptake after 10 mins by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Emory University

Curated by PDSP Ki Database
LigandPNGBDBM82071(NSC_62923 | WY-45030 | VENLAFAXINE | CAS_93413-69-...)
Affinity DataIC50: 20nMAssay Description:Inhibition of SERTMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Rat)
Wyeth Laboratories

Curated by PDSP Ki Database
LigandPNGBDBM82071(NSC_62923 | WY-45030 | VENLAFAXINE | CAS_93413-69-...)
Affinity DataKi:  24.5nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2012
Entry Details
PubMed
TargetSodium-dependent serotonin transporter(Human)
Emory University

Curated by PDSP Ki Database
LigandPNGBDBM82071(NSC_62923 | WY-45030 | VENLAFAXINE | CAS_93413-69-...)
Affinity DataIC50: 27nMAssay Description:Inhibition of human SERT expressed in human JAR cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/19/2010
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Emory University

Curated by PDSP Ki Database
LigandPNGBDBM82071(NSC_62923 | WY-45030 | VENLAFAXINE | CAS_93413-69-...)
Affinity DataIC50: 31nMAssay Description:Inhibition of 5HT uptake at human SERT expressed in human JAR cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Emory University

Curated by PDSP Ki Database
LigandPNGBDBM82071(NSC_62923 | WY-45030 | VENLAFAXINE | CAS_93413-69-...)
Affinity DataIC50: 35nMAssay Description:Inhibition of serotonin reuptake at human SERT expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/1/2013
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Emory University

Curated by PDSP Ki Database
LigandPNGBDBM82071(NSC_62923 | WY-45030 | VENLAFAXINE | CAS_93413-69-...)
Affinity DataIC50: 36nMAssay Description:Inhibition of human SERT expressed in HEK293 cells at incubated for 15 mins by neurotransmitter reuptake assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/7/2016
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Emory University

Curated by PDSP Ki Database
LigandPNGBDBM82071(NSC_62923 | WY-45030 | VENLAFAXINE | CAS_93413-69-...)
Affinity DataIC50: 36nMAssay Description:Inhibition of serotonin reuptake at human SERT expressed in HEK293 cells after 15 mins by fluorescence neurotransmitter transporter assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/24/2016
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Rat)
Wyeth Laboratories

Curated by PDSP Ki Database
LigandPNGBDBM82071(NSC_62923 | WY-45030 | VENLAFAXINE | CAS_93413-69-...)
Affinity DataKi:  37nMAssay Description:Inhibition of [3H]5-HT reuptake into rat frontal cortex synaptosomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/29/2012
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Emory University

Curated by PDSP Ki Database
LigandPNGBDBM82071(NSC_62923 | WY-45030 | VENLAFAXINE | CAS_93413-69-...)
Affinity DataKi:  39nMAssay Description:Binding affinity to human SERT expressed in HEK293 cells after 60 mins in presence of [3H]imipramine by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/16/2020
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Rat)
Wyeth Laboratories

Curated by PDSP Ki Database
LigandPNGBDBM82071(NSC_62923 | WY-45030 | VENLAFAXINE | CAS_93413-69-...)
Affinity DataKi:  52nMAssay Description:Binding affinity to the serotonin transporter (SERT) measured by displacement of [3H]paroxetine in male wistar ratsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2012
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Rat)
Wyeth Laboratories

Curated by PDSP Ki Database
LigandPNGBDBM82071(NSC_62923 | WY-45030 | VENLAFAXINE | CAS_93413-69-...)
Affinity DataKi:  74nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/27/2012
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Rat)
Wyeth Laboratories

Curated by PDSP Ki Database
LigandPNGBDBM82071(NSC_62923 | WY-45030 | VENLAFAXINE | CAS_93413-69-...)
Affinity DataKi:  74nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
4/11/2012
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Emory University

Curated by PDSP Ki Database
LigandPNGBDBM82071(NSC_62923 | WY-45030 | VENLAFAXINE | CAS_93413-69-...)
Affinity DataKi:  75.9nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2012
Entry Details
PubMed
TargetSodium-dependent serotonin transporter(Human)
Emory University

Curated by PDSP Ki Database
LigandPNGBDBM82071(NSC_62923 | WY-45030 | VENLAFAXINE | CAS_93413-69-...)
Affinity DataKi:  82nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2012
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Emory University

Curated by PDSP Ki Database
LigandPNGBDBM82071(NSC_62923 | WY-45030 | VENLAFAXINE | CAS_93413-69-...)
Affinity DataKi:  82nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/29/2012
Entry Details Article
PubMed
TargetAlpha-1A adrenergic receptor(Rat)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM82071(NSC_62923 | WY-45030 | VENLAFAXINE | CAS_93413-69-...)
Affinity DataIC50: 90nMAssay Description:Inhibition of binding of [3H]imipramine to imipramine receptor in rat brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2012
Entry Details Article
PubMed
TargetAlpha-1A adrenergic receptor(Rat)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM82071(NSC_62923 | WY-45030 | VENLAFAXINE | CAS_93413-69-...)
Affinity DataIC50: 90nMAssay Description:Inhibition of binding of [3H]imipramine to imipramine receptor in rat brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2012
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Rat)
Wyeth Laboratories

Curated by PDSP Ki Database
LigandPNGBDBM82071(NSC_62923 | WY-45030 | VENLAFAXINE | CAS_93413-69-...)
Affinity DataKi:  90nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2011
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Rat)
Wyeth Laboratories

Curated by PDSP Ki Database
LigandPNGBDBM82071(NSC_62923 | WY-45030 | VENLAFAXINE | CAS_93413-69-...)
Affinity DataIC50: 100nMAssay Description:Inhibition of uptake of tritiated serotonin (5-HT) into rat brain synaptosomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2012
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Emory University

Curated by PDSP Ki Database
LigandPNGBDBM82071(NSC_62923 | WY-45030 | VENLAFAXINE | CAS_93413-69-...)
Affinity DataKi:  102nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/1/2012
Entry Details
PubMed
TargetAlpha-1A adrenergic receptor(Rat)
Wyeth-Ayerst Research

Curated by ChEMBL
LigandPNGBDBM82071(NSC_62923 | WY-45030 | VENLAFAXINE | CAS_93413-69-...)
Affinity DataIC50: 109nMAssay Description:Inhibition of binding of [3H]imipramine to imipramine receptor in rat brainMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2012
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Rat)
Wyeth Laboratories

Curated by PDSP Ki Database
LigandPNGBDBM82071(NSC_62923 | WY-45030 | VENLAFAXINE | CAS_93413-69-...)
Affinity DataKi:  109nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2011
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Rat)
Wyeth Laboratories

Curated by PDSP Ki Database
LigandPNGBDBM82071(NSC_62923 | WY-45030 | VENLAFAXINE | CAS_93413-69-...)
Affinity DataKi:  138nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/2/2012
Entry Details Article
PubMed
TargetTransporter(Rat)
Hong Kong University of Science and Technology

Curated by ChEMBL
LigandPNGBDBM82071(NSC_62923 | WY-45030 | VENLAFAXINE | CAS_93413-69-...)
Affinity DataKi:  138nMAssay Description:Inhibition of [3H]- NE reuptake into rat hippocampal synaptosomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/29/2012
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Rat)
Wyeth Laboratories

Curated by PDSP Ki Database
LigandPNGBDBM82071(NSC_62923 | WY-45030 | VENLAFAXINE | CAS_93413-69-...)
Affinity DataKi:  140nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/25/2011
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Emory University

Curated by PDSP Ki Database
LigandPNGBDBM82071(NSC_62923 | WY-45030 | VENLAFAXINE | CAS_93413-69-...)
Affinity DataKi:  145nMMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/29/2012
Entry Details Article
PubMed
TargetSodium-dependent noradrenaline transporter(Human)
Csir-National Chemical Laboratory

Curated by ChEMBL
LigandPNGBDBM82071(NSC_62923 | WY-45030 | VENLAFAXINE | CAS_93413-69-...)
Affinity DataIC50: 149nMAssay Description:Inhibition of human NET expressed in MDCK cells assessed as decrease in [3H]-noradrenaline reuptake after 10 mins by scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetSodium-dependent noradrenaline transporter(Human)
Csir-National Chemical Laboratory

Curated by ChEMBL
LigandPNGBDBM82071(NSC_62923 | WY-45030 | VENLAFAXINE | CAS_93413-69-...)
Affinity DataIC50: 149nMAssay Description:Inhibition of NETMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2013
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Emory University

Curated by PDSP Ki Database
LigandPNGBDBM82071(NSC_62923 | WY-45030 | VENLAFAXINE | CAS_93413-69-...)
Affinity DataIC50: 200nMAssay Description:Inhibition of [3H]-5-HT reuptake in human SERT transfected into HEK293 cells by liquid scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/10/2017
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Emory University

Curated by PDSP Ki Database
LigandPNGBDBM82071(NSC_62923 | WY-45030 | VENLAFAXINE | CAS_93413-69-...)
Affinity DataIC50: 200nMAssay Description:Inhibition of [3H]serotonin uptake at human SERT expressed in HEK293 cells after 15 to 20 mins by microbeta scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2020
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Emory University

Curated by PDSP Ki Database
LigandPNGBDBM82071(NSC_62923 | WY-45030 | VENLAFAXINE | CAS_93413-69-...)
Affinity DataIC50: 200nMAssay Description:Inhibition of [3H]-5-hydroxytryptamine reuptake in human SERT expressed in HEK293 cells by liquid scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/28/2021
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Emory University

Curated by PDSP Ki Database
LigandPNGBDBM82071(NSC_62923 | WY-45030 | VENLAFAXINE | CAS_93413-69-...)
Affinity DataIC50: 200nMAssay Description:Inhibition of human SERT expressed in HEK293 cells assessed as reduction in [3H]5-HT uptake by micro beta scintillation counting analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/17/2020
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Emory University

Curated by PDSP Ki Database
LigandPNGBDBM82071(NSC_62923 | WY-45030 | VENLAFAXINE | CAS_93413-69-...)
Affinity DataIC50: 200nMAssay Description:Inhibition of [3H]-5-hydroxytryptamine reuptake in human SERT expressed in HEK293 cells by microbeta liquid scintillation counting methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/7/2019
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Emory University

Curated by PDSP Ki Database
LigandPNGBDBM82071(NSC_62923 | WY-45030 | VENLAFAXINE | CAS_93413-69-...)
Affinity DataIC50: 200nMAssay Description:Inhibition of re-uptake of [3H]-5-HT at human SERT expressed in HEK293 cells by liquid scintillation countingMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/17/2020
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Emory University

Curated by PDSP Ki Database
LigandPNGBDBM82071(NSC_62923 | WY-45030 | VENLAFAXINE | CAS_93413-69-...)
Affinity DataIC50: 204nMAssay Description:Inhibition of human SERT expressed in HEK293 cells assessed as reduction of serotonin reuptake using [3H]-SERT after 15 mins by liquid scintillation ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/30/2016
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Rat)
Wyeth Laboratories

Curated by PDSP Ki Database
LigandPNGBDBM82071(NSC_62923 | WY-45030 | VENLAFAXINE | CAS_93413-69-...)
Affinity DataIC50: 210nMAssay Description:Inhibition of uptake of tritiated serotonin (5-HT) into rat brain synaptosomesMore data for this Ligand-Target Pair
In Depth
Date in BDB:
10/19/2012
Entry Details Article
PubMed
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