BDBM50012184 CHEMBL1092509

SMILES O\N=C1\C(\Nc2ccccc\12)=C1\C(=O)Nc2c1cccc2Br

InChI Key InChIKey=VJTWDKLJCDHHRX-FQJRYBMTSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50012184   

TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Friedrich-Schiller-University

Curated by ChEMBL
LigandPNGBDBM50012184(CHEMBL1092509)
Affinity DataIC50:  5.80E+3nMAssay Description:Inhibition of human recombinant 5-LO assessed as product formation by cell-free assay relative to controlMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Friedrich-Schiller-University

Curated by ChEMBL
LigandPNGBDBM50012184(CHEMBL1092509)
Affinity DataIC50:  1.70E+3nMAssay Description:Inhibition of 5-LO in human neutrophils assessed as product formation by cell-intact assay relative to control in presence of 2.5 uM A23187 ionophoreMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Friedrich-Schiller-University

Curated by ChEMBL
LigandPNGBDBM50012184(CHEMBL1092509)
Affinity DataIC50:  3.60E+3nMAssay Description:Inhibition of 5-LO in human neutrophils assessed as product formation by cell-intact assay relative to control in presence of 20 uM A23187/AA ionopho...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase C(Homo sapiens (Human))
Zunyi Medical University

Curated by ChEMBL
LigandPNGBDBM50012184(CHEMBL1092509)
Affinity DataIC50:  100nMAssay Description:Inhibition of Aurora C (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetGlycogen synthase kinase-3 beta/[Tau protein] kinase(Sus scrofa)
Zunyi Medical University

Curated by ChEMBL
LigandPNGBDBM50012184(CHEMBL1092509)
Affinity DataIC50:  3.20E+4nMAssay Description:Inhibition of porcine brain GSK-3alpha/beta incubated for 30 mins in presence of [33p]-gamma ATP by scintillation counter analysisMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetAurora kinase A(Homo sapiens (Human))
Zunyi Medical University

Curated by ChEMBL
LigandPNGBDBM50012184(CHEMBL1092509)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of Aurora A (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetAurora kinase B(Homo sapiens (Human))
Zunyi Medical University

Curated by ChEMBL
LigandPNGBDBM50012184(CHEMBL1092509)
Affinity DataIC50:  4.60E+3nMAssay Description:Inhibition of Aurora B (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCyclin-dependent kinase 5 activator 1(Homo sapiens (Human))
Zunyi Medical University

Curated by ChEMBL
LigandPNGBDBM50012184(CHEMBL1092509)
Affinity DataIC50:  3.30E+4nMAssay Description:Inhibition of GST-fused CDK5/p25 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed