BDBM50012184 CHEMBL1092509
SMILES O\N=C1\C(\Nc2ccccc\12)=C1\C(=O)Nc2c1cccc2Br
InChI Key InChIKey=VJTWDKLJCDHHRX-FQJRYBMTSA-N
Data 8 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 8 hits for monomerid = 50012184
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Friedrich-Schiller-University
Curated by ChEMBL
Friedrich-Schiller-University
Curated by ChEMBL
Affinity DataIC50: 5.80E+3nMAssay Description:Inhibition of human recombinant 5-LO assessed as product formation by cell-free assay relative to controlMore data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Friedrich-Schiller-University
Curated by ChEMBL
Friedrich-Schiller-University
Curated by ChEMBL
Affinity DataIC50: 1.70E+3nMAssay Description:Inhibition of 5-LO in human neutrophils assessed as product formation by cell-intact assay relative to control in presence of 2.5 uM A23187 ionophoreMore data for this Ligand-Target Pair
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Friedrich-Schiller-University
Curated by ChEMBL
Friedrich-Schiller-University
Curated by ChEMBL
Affinity DataIC50: 3.60E+3nMAssay Description:Inhibition of 5-LO in human neutrophils assessed as product formation by cell-intact assay relative to control in presence of 20 uM A23187/AA ionopho...More data for this Ligand-Target Pair
Affinity DataIC50: 100nMAssay Description:Inhibition of Aurora C (unknown origin)More data for this Ligand-Target Pair
TargetGlycogen synthase kinase-3 beta/[Tau protein] kinase(Sus scrofa)
Zunyi Medical University
Curated by ChEMBL
Zunyi Medical University
Curated by ChEMBL
Affinity DataIC50: 3.20E+4nMAssay Description:Inhibition of porcine brain GSK-3alpha/beta incubated for 30 mins in presence of [33p]-gamma ATP by scintillation counter analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 2.00E+3nMAssay Description:Inhibition of Aurora A (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 4.60E+3nMAssay Description:Inhibition of Aurora B (unknown origin)More data for this Ligand-Target Pair
TargetCyclin-dependent kinase 5 activator 1(Homo sapiens (Human))
Zunyi Medical University
Curated by ChEMBL
Zunyi Medical University
Curated by ChEMBL
Affinity DataIC50: 3.30E+4nMAssay Description:Inhibition of GST-fused CDK5/p25 (unknown origin)More data for this Ligand-Target Pair