BDBM50013093 2-(3-Ethyl-4-methyl-phenylamino)-1,9-dihydro-purin-6-one::CHEMBL16026

SMILES CCc1cc(Nc2nc3nc[nH]c3c(=O)[nH]2)ccc1C

InChI Key InChIKey=JUIJZZPKQVQVDL-UHFFFAOYSA-N

Data  3 KI  4 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50013093   

TargetDNA polymerase III PolC-type(Bacillus subtilis)
Glsynthesis

Curated by ChEMBL
LigandPNGBDBM50013093(2-(3-Ethyl-4-methyl-phenylamino)-1,9-dihydro-purin...)
Affinity DataKi:  2.70E+3nMAssay Description:Inhibitory constant against DNA polymerases IIIC produced by Bacillus subtilis; (a)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase III subunit alpha(Bacillus subtilis)
Glsynthesis

Curated by ChEMBL
LigandPNGBDBM50013093(2-(3-Ethyl-4-methyl-phenylamino)-1,9-dihydro-purin...)
Affinity DataKi: >2.48E+5nMAssay Description:Inhibitory constant against DNA polymerases IIIE from Bacillus subtilis; (a)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase alpha catalytic subunit(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50013093(2-(3-Ethyl-4-methyl-phenylamino)-1,9-dihydro-purin...)
Affinity DataKi:  1.76E+6nMAssay Description:Compound was evaluated for the concentration which gives half-maximal inhibition of Chinese Hamster Ovary DNA polymerase alphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidine kinase(Human herpesvirus 1 (strain SC16) (HHV-1) (Human h...)
University Of Massachusetts Medical School

Curated by ChEMBL
LigandPNGBDBM50013093(2-(3-Ethyl-4-methyl-phenylamino)-1,9-dihydro-purin...)
Affinity DataIC50:  6.92E+3nMAssay Description:Inhibitory activity against HSV-1 thymidine kinase isolated from HeLa cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidine kinase(Human herpesvirus 1)
University Of Massachusetts Medical School

Curated by ChEMBL
LigandPNGBDBM50013093(2-(3-Ethyl-4-methyl-phenylamino)-1,9-dihydro-purin...)
Affinity DataIC50:  7.00E+3nMAssay Description:Inhibition of TdR phosphorylation using thymidine kinase assay for herpes simplex virus type 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidine kinase(Human herpesvirus 1 (strain SC16) (HHV-1) (Human h...)
University Of Massachusetts Medical School

Curated by ChEMBL
LigandPNGBDBM50013093(2-(3-Ethyl-4-methyl-phenylamino)-1,9-dihydro-purin...)
Affinity DataIC50:  8.00E+3nMAssay Description:Inhibition of TdR phosphorylation using thymidine kinase assay for herpes simplex virus type 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidine kinase(Human herpesvirus 2)
University Of Massachusetts Medical School

Curated by ChEMBL
LigandPNGBDBM50013093(2-(3-Ethyl-4-methyl-phenylamino)-1,9-dihydro-purin...)
Affinity DataIC50:  7.94E+3nMAssay Description:Inhibitory activity against HSV-2 thymidine kinase isolated from HeLa cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThymidine kinase(Human herpesvirus 1 (strain SC16) (HHV-1) (Human h...)
University Of Massachusetts Medical School

Curated by ChEMBL
LigandPNGBDBM50013093(2-(3-Ethyl-4-methyl-phenylamino)-1,9-dihydro-purin...)
Affinity DataEC50:  7.00E+3nMAssay Description:Inhibition of (-)-[3H]-nicotine binding to rat brain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed