BDBM50014577 CHEMBL286722::MDL-2170::Z-Val-Phe-H::[(S)-1-((S)-1-Benzyl-2-oxo-ethylcarbamoyl)-2-methyl-propyl]-carbamic acid benzyl ester::[1-(1-Formyl-2-phenyl-ethylcarbamoyl)-2-methyl-propyl]-carbamic acid benzyl ester::benzyl (S)-3-methyl-1-oxo-1-((S)-1-oxo-3-phenylpropan-2-ylamino)butan-2-ylcarbamate

SMILES CC(C)[C@H](NC(=O)OCc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C=O

InChI Key InChIKey=NGBKFLTYGSREKK-PMACEKPBSA-N

Data  4 KI  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50014577   

TargetCalpain-1 catalytic subunit(Homo sapiens (Human))
Cephalon

Curated by ChEMBL
LigandPNGBDBM50014577(CHEMBL286722 | MDL-2170 | Z-Val-Phe-H | [(S)-1-((S...)
Affinity DataKi:  8nMAssay Description:Inhibitory activity against recombinant human Calpain-I receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalpain-1 catalytic subunit(Sus scrofa (pig))
University Of Tennessee Health Science Center

Curated by ChEMBL
LigandPNGBDBM50014577(CHEMBL286722 | MDL-2170 | Z-Val-Phe-H | [(S)-1-((S...)
Affinity DataKi:  10nMAssay Description:Inhibition of mu-calpain in porcine erythrocyte using Suc-Leu-Tyr-AMC as substrate by microtiter plate assay based Dixon plot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin B(Homo sapiens (Human))
Cephalon

Curated by ChEMBL
LigandPNGBDBM50014577(CHEMBL286722 | MDL-2170 | Z-Val-Phe-H | [(S)-1-((S...)
Affinity DataKi:  24nMAssay Description:Inhibitory activity against cathepsin B receptor in human liverMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChymotrypsinogen A(Bos taurus (bovine))
Merrell Dow Research Institute

Curated by ChEMBL
LigandPNGBDBM50014577(CHEMBL286722 | MDL-2170 | Z-Val-Phe-H | [(S)-1-((S...)
Affinity DataKi:  5.40E+4nMAssay Description:Inhibition of alpha-chymotrypsinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Jadavpur University

Curated by ChEMBL
LigandPNGBDBM50014577(CHEMBL286722 | MDL-2170 | Z-Val-Phe-H | [(S)-1-((S...)
Affinity DataIC50: >2.00E+4nMAssay Description:Inhibition of SARS-CoV-2 MProMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCalpain small subunit 1/1 catalytic subunit(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50014577(CHEMBL286722 | MDL-2170 | Z-Val-Phe-H | [(S)-1-((S...)
Affinity DataIC50:  40nMAssay Description:Inhibition of Calpain 1 by [3H]-acetyl-casein assayMore data for this Ligand-Target Pair
In DepthDetails Article
TargetCalpain-1 catalytic subunit(Homo sapiens (Human))
Cephalon

Curated by ChEMBL
LigandPNGBDBM50014577(CHEMBL286722 | MDL-2170 | Z-Val-Phe-H | [(S)-1-((S...)
Affinity DataIC50:  300nMAssay Description:Inhibition of intracellular Calpain-I receptor using intact cell assay systemMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed