BDBM50015011 CHEMBL3262363::US9259422, 7a, 2-MePh- BU10101::US9480684, 7a, 2- MePh- BU10101

SMILES [H][C@@]12Oc3c4c(C[C@@]5([H])N(CC6CC6)CC[C@@]14[C@@]51CC[C@@]2(OC)[C@]([H])(C1)[C@](C)(O)c1ccccc1C)ccc3O

InChI Key InChIKey=MCJYXNRYAYCDAR-PPMCTTEPSA-N

Data  6 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50015011   

TargetKappa-type opioid receptor(Homo sapiens (Human))
University Of Bath

Curated by ChEMBL
LigandPNGBDBM50015011(CHEMBL3262363 | US9259422, 7a, 2-MePh- BU10101 | U...)
Affinity DataKi:  0.160nMAssay Description:Displacement of [3H]diprenorphine from recombinant human kappa opioid receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetKappa-type opioid receptor(Homo sapiens (Human))
University Of Bath

Curated by ChEMBL
LigandPNGBDBM50015011(CHEMBL3262363 | US9259422, 7a, 2-MePh- BU10101 | U...)
Affinity DataKi:  0.160nMpH: 7.4Assay Description:As Alt et al., 2002. Membranes (20 μg) are incubated in 50 mM Tris-HCl, pH 7.4 with [3H]diprenorphine or [3H]nociceptin in the absence or presen...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetKappa-type opioid receptor(Homo sapiens (Human))
University Of Bath

Curated by ChEMBL
LigandPNGBDBM50015011(CHEMBL3262363 | US9259422, 7a, 2-MePh- BU10101 | U...)
Affinity DataKi:  0.160nM ΔG°:  -13.4kcal/molepH: 7.4 T: 2°CAssay Description:As Alt et al., 2002. Membranes (20 ug) are incubated in 50 mM Tris-HCl, pH 7.4 with [3H]diprenorphine or [3H]nociceptin in the absence or presence ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMu-type opioid receptor(Rattus norvegicus (rat))
University Of Bath

Curated by ChEMBL
LigandPNGBDBM50015011(CHEMBL3262363 | US9259422, 7a, 2-MePh- BU10101 | U...)
Affinity DataKi:  0.190nMAssay Description:Displacement of [3H]diprenorphine from rat mu opioid receptor expressed in rat C6 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMu-type opioid receptor(Rattus norvegicus (rat))
University Of Bath

Curated by ChEMBL
LigandPNGBDBM50015011(CHEMBL3262363 | US9259422, 7a, 2-MePh- BU10101 | U...)
Affinity DataKi:  0.190nM ΔG°:  -13.3kcal/molepH: 7.4 T: 2°CAssay Description:As Alt et al., 2002. Membranes (20 ug) are incubated in 50 mM Tris-HCl, pH 7.4 with [3H]diprenorphine or [3H]nociceptin in the absence or presence ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMu-type opioid receptor(Rattus norvegicus (rat))
University Of Bath

Curated by ChEMBL
LigandPNGBDBM50015011(CHEMBL3262363 | US9259422, 7a, 2-MePh- BU10101 | U...)
Affinity DataKi:  0.190nMpH: 7.4Assay Description:As Alt et al., 2002. Membranes (20 μg) are incubated in 50 mM Tris-HCl, pH 7.4 with [3H]diprenorphine or [3H]nociceptin in the absence or presen...More data for this Ligand-Target Pair
In DepthDetails US Patent