BDBM50016784 ALLOPURINOL::BW-56-158::BW-56158::CHEBI:40279::Lopurin::US10093631, Compound Allopurinol::US9428466, Allopurinol::Zyloprim

SMILES O=c1ncnc2[nH][nH]cc12

InChI Key InChIKey=IUYQIJQHYDZUDF-UHFFFAOYSA-N

Data  4 KI  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50016784   

TargetXanthine dehydrogenase/oxidase(Bos taurus (Bovine))
TBA

Curated by ChEMBL
LigandPNGBDBM50016784(ALLOPURINOL | BW-56-158 | BW-56158 | CHEBI:40279 |...)
Affinity DataKi:  1.00E+3nMAssay Description:Mixed-type inhibition of bovine milk xanthine oxidase using xanthine as substrate by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetXanthine dehydrogenase/oxidase(Homo sapiens (Human))
Universidade Estadual De Campinas

Curated by ChEMBL
LigandPNGBDBM50016784(ALLOPURINOL | BW-56-158 | BW-56158 | CHEBI:40279 |...)
Affinity DataKi:  1.55E+3nMAssay Description:Non-competitive inhibition of xanthine oxidase (unknown origin) by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetXanthine dehydrogenase/oxidase(Bos taurus (Bovine))
TBA

Curated by ChEMBL
LigandPNGBDBM50016784(ALLOPURINOL | BW-56-158 | BW-56158 | CHEBI:40279 |...)
Affinity DataKi:  2.60E+3nMAssay Description:Mixed-type inhibition of bovine milk xanthine oxidase using hypoxanthine as substrate by Lineweaver-Burk plot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetXanthine dehydrogenase/oxidase(Homo sapiens (Human))
Universidade Estadual De Campinas

Curated by ChEMBL
LigandPNGBDBM50016784(ALLOPURINOL | BW-56-158 | BW-56158 | CHEBI:40279 |...)
Affinity DataKi:  7.30E+3nMAssay Description:Inhibition of xanthine oxidase (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetBile salt export pump(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50016784(ALLOPURINOL | BW-56-158 | BW-56158 | CHEBI:40279 |...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of recombinant human BSEP expressed in baculovirus infected sf9 cell membrane vesicles assessed as reduction in ATP or AMP-dependent [3H]-...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetXanthine dehydrogenase/oxidase(Homo sapiens (Human))
Universidade Estadual De Campinas

Curated by ChEMBL
LigandPNGBDBM50016784(ALLOPURINOL | BW-56-158 | BW-56158 | CHEBI:40279 |...)
Affinity DataIC50:  3.50E+3nMAssay Description:Xanthine oxidase inhibition was determined using a standard fluorescence-based assay for xanthine oxidase activity (McHale A, Grimes H, Coughlan M P:...More data for this Ligand-Target Pair
In DepthDetails US PatentDrugBank

TargetSolute carrier family 22 member 12(Homo sapiens (Human))
Acquist

US Patent
LigandPNGBDBM50016784(ALLOPURINOL | BW-56-158 | BW-56158 | CHEBI:40279 |...)
Affinity DataIC50: >3.00E+5nMAssay Description:URAT1 (SLC22A12) activity was evaluated in a cellular uptake assay using a 96-well plate with stably transfected URAT-1/CHO cells. 3H-orotate was use...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetXanthine dehydrogenase/oxidase(Bos taurus (Bovine))
TBA

Curated by ChEMBL
LigandPNGBDBM50016784(ALLOPURINOL | BW-56-158 | BW-56158 | CHEBI:40279 |...)
Affinity DataIC50:  1.11E+4nMAssay Description:Inhibition of bovine xanthine oxidase assessed as reduction in uric acid formation using xanthine as substrate pretreated for 5 mins followed by subs...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetXanthine dehydrogenase/oxidase(Homo sapiens (Human))
Universidade Estadual De Campinas

Curated by ChEMBL
LigandPNGBDBM50016784(ALLOPURINOL | BW-56-158 | BW-56158 | CHEBI:40279 |...)
Affinity DataIC50:  2.13E+3nMAssay Description:Xanthine oxidase inhibition was determined using a standard fluorescence-based assay for xanthine oxidase activity (McHale A, Grimes H, Coughlan M P:...More data for this Ligand-Target Pair
In DepthDetails US PatentDrugBank

TargetXanthine dehydrogenase/oxidase(Homo sapiens (Human))
Universidade Estadual De Campinas

Curated by ChEMBL
LigandPNGBDBM50016784(ALLOPURINOL | BW-56-158 | BW-56158 | CHEBI:40279 |...)
Affinity DataIC50:  2.90E+3nMAssay Description:Inhibition of xanthine oxidase (unknown origin) using xanthine as substrate preincubated for 15 mins followed by substrate addition measured after 30...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank