BDBM50016986 7-Chloro-2-(4-methoxy-benzyl)-3-methyl-5-propyl-benzofuran-4-ol::CHEMBL17815

SMILES CCCc1cc(Cl)c2oc(Cc3ccc(OC)cc3)c(C)c2c1O

InChI Key InChIKey=PLRQEJPVGOQVSJ-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50016986   

TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Merck Frosst Canada

Curated by ChEMBL
LigandPNGBDBM50016986(7-Chloro-2-(4-methoxy-benzyl)-3-methyl-5-propyl-be...)
Affinity DataIC50:  400nMAssay Description:Inhibition of 5-lipoxygenase reaction catalyzed by purified enzyme from porcine leukocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Rattus norvegicus)
Merck Frosst Canada

Curated by ChEMBL
LigandPNGBDBM50016986(7-Chloro-2-(4-methoxy-benzyl)-3-methyl-5-propyl-be...)
Affinity DataIC50:  36nMAssay Description:Concentration required for 50 % inhibition of arachidonic acid oxidation by rat 5-lipoxygenaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Homo sapiens (Human))
Merck Frosst Canada

Curated by ChEMBL
LigandPNGBDBM50016986(7-Chloro-2-(4-methoxy-benzyl)-3-methyl-5-propyl-be...)
Affinity DataIC50:  4.00E+4nMAssay Description:Inhibition of partially purified 15-lipoxygenase from human leukocytesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid 5-lipoxygenase(Homo sapiens (Human))
Merck Frosst Canada

Curated by ChEMBL
LigandPNGBDBM50016986(7-Chloro-2-(4-methoxy-benzyl)-3-methyl-5-propyl-be...)
Affinity DataIC50:  11nMAssay Description:Concentration required for 50 % inhibition of leukotriene B4 production in human PMN compared with controls in the absence of compoundMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyunsaturated fatty acid lipoxygenase ALOX15(Sus scrofa)
Merck Frosst Canada

Curated by ChEMBL
LigandPNGBDBM50016986(7-Chloro-2-(4-methoxy-benzyl)-3-methyl-5-propyl-be...)
Affinity DataIC50:  4.00E+4nMAssay Description:Inhibitory activity of the compound towards porcine 12-lipoxygenaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSeed linoleate 13S-lipoxygenase-1(Glycine max (soybean))
Merck Frosst Canada

Curated by ChEMBL
LigandPNGBDBM50016986(7-Chloro-2-(4-methoxy-benzyl)-3-methyl-5-propyl-be...)
Affinity DataIC50:  3.00E+4nMAssay Description:Inhibitory activity of the compound towards soybean lipoxygenaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed