BDBM50017101 7,8-Dimethoxy-1,2,3a,4,5,9b-hexahydro-benzo[e]isoindol-3-one::CHEMBL35053

SMILES COc1cc2CC[C@H]3[C@@H](CNC3=O)c2cc1OC

InChI Key InChIKey=QWQNNBPCVVLDDY-GXSJLCMTSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50017101   

TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Bos taurus)
Centre De Neurochimie Du Cnrs

Curated by ChEMBL
LigandPNGBDBM50017101(7,8-Dimethoxy-1,2,3a,4,5,9b-hexahydro-benzo[e]isoi...)
Affinity DataIC50: >1.00E+6nMAssay Description:Inhibition of cGMP-PDE phosphodiesterase from bovine aorta using 1 uM cGMP (insignificant)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50017101(7,8-Dimethoxy-1,2,3a,4,5,9b-hexahydro-benzo[e]isoi...)
Affinity DataIC50: >1.00E+6nMAssay Description:Inhibition of phosphodiesterase from bovine aorta with 1 uM cGMP calcium (10 uM) and calmodulin (15 nM) (insignificant)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Centre De Neurochimie Du Cnrs

Curated by ChEMBL
LigandPNGBDBM50017101(7,8-Dimethoxy-1,2,3a,4,5,9b-hexahydro-benzo[e]isoi...)
Affinity DataIC50:  1.38E+5nMAssay Description:Inhibitory activity against phosphodiesterase was determined in vitro using bovine aorta, at 1 uM cAMP for cAMP-PDE.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed