BDBM50018286 CHEMBL3290335

SMILES C[C@@H]1CN(CCN1c1ccc(cn1)C#N)c1nnc(Cc2ccccc2)c2ccc(cc12)C#N

InChI Key InChIKey=XGAKLPIDELWBDY-LJQANCHMSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50018286   

TargetSphingosine-1-phosphate lyase 1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50018286(CHEMBL3290335)
Affinity DataIC50:  24nMAssay Description:Inhibition of human recombinant S1PL (62 to 568) expressed in Sf9 insect cells using S1P as substrate after 1 hrMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine-1-phosphate lyase 1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50018286(CHEMBL3290335)
Affinity DataIC50:  94nMAssay Description:Inhibition of human S1PL using RBM13 as substrate measured after 1 hr by fluorogenic assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSmoothened homolog(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50018286(CHEMBL3290335)
Affinity DataIC50: >2.50E+4nMAssay Description:Antagonist activity at smoothened (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed