BDBM50018958 CHEBI:75401::QUINPIROLE

SMILES [H][C@]12CCCN(CCC)[C@]1([H])Cc1c[nH]nc1C2

InChI Key InChIKey=FTSUPYGMFAPCFZ-ZWNOBZJWSA-N

Data  24 KI  4 IC50  61 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 89 hits for monomerid = 50018958   

TargetD(2) dopamine receptor(Homo sapiens (Human))
Columbia University College of Physicians and Surgeons

Curated by ChEMBL
LigandPNGBDBM50018958(CHEBI:75401 | QUINPIROLE)
Affinity DataKi:  5.60nMAssay Description:Displacement of [3H]7-OH-DPAT from human D2 receptor transfected in HEK293 cells measured after 60 mins by liquid scintillation counterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Homo sapiens (Human))
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50018958(CHEBI:75401 | QUINPIROLE)
Affinity DataKi:  6.80nMAssay Description:Displacement of [3H]-(R)-(+)-7-OH-DPAT from human dopamine D3 receptor expressed in HEK293 cell membranes after 90 mins by micro beta scintillation c...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Homo sapiens (Human))
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50018958(CHEBI:75401 | QUINPIROLE)
Affinity DataKi:  8nMAssay Description:Displacement of [3H]7-OH-DPAT from human D3 receptor transfected in HEK293 cells measured after 60 mins by liquid scintillation counterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(4) dopamine receptor(Homo sapiens (Human))
Friedrich-Alexander University

Curated by ChEMBL
LigandPNGBDBM50018958(CHEBI:75401 | QUINPIROLE)
Affinity DataKi:  8.5nMAssay Description:Displacement of [3H]spiperone from human D4.4 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Columbia University College of Physicians and Surgeons

Curated by ChEMBL
LigandPNGBDBM50018958(CHEBI:75401 | QUINPIROLE)
Affinity DataKi:  13nMAssay Description:Displacement of [3H]-(R)-(+)-7-OH-DPAT from human dopamine D2 receptor expressed in HEK293 cell membranes after 90 mins by micro beta scintillation c...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Homo sapiens (Human))
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50018958(CHEBI:75401 | QUINPIROLE)
Affinity DataKi:  15nMAssay Description:Displacement of [3H]Spiperone from human dopamine D3 receptor expressed in CHO cells by competitive binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Homo sapiens (Human))
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50018958(CHEBI:75401 | QUINPIROLE)
Affinity DataKi:  15nMAssay Description:Displacement of [3H]spiperone from human D3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Homo sapiens (Human))
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50018958(CHEBI:75401 | QUINPIROLE)
Affinity DataKi:  15nMAssay Description:Displacement of [3H]spiperone from human dopamine D3 receptor transfected in CHO cells after 1 hr by scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Homo sapiens (Human))
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50018958(CHEBI:75401 | QUINPIROLE)
Affinity DataKi:  29nMAssay Description:Displacement of [3H]N-methylspiperone from human D3 receptor transfected in HEK293 cells measured after 60 mins by liquid scintillation counterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))TBA
LigandPNGBDBM50018958(CHEBI:75401 | QUINPIROLE)
Affinity DataKi:  63nMAssay Description:Binding affinity against Dopamine receptor D2 in rat striatal membranes using [3H]spiperoneMore data for this Ligand-Target Pair
In DepthDetails
TargetD(2) dopamine receptor(Homo sapiens (Human))
Columbia University College of Physicians and Surgeons

Curated by ChEMBL
LigandPNGBDBM50018958(CHEBI:75401 | QUINPIROLE)
Affinity DataKi:  70nMAssay Description:Displacement of [3H]Spiperone from human dopamine D2 short receptor expressed in CHO cells by competitive binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Columbia University College of Physicians and Surgeons

Curated by ChEMBL
LigandPNGBDBM50018958(CHEBI:75401 | QUINPIROLE)
Affinity DataKi:  70nMAssay Description:Displacement of [3H]spiperone from human dopamine D2S receptor transfected in CHO cells after 1 hr by scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Columbia University College of Physicians and Surgeons

Curated by ChEMBL
LigandPNGBDBM50018958(CHEBI:75401 | QUINPIROLE)
Affinity DataKi:  70nMAssay Description:Displacement of [3H]spiperone from human D2S receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Homo sapiens (Human))
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50018958(CHEBI:75401 | QUINPIROLE)
Affinity DataKi:  100nMAssay Description:Tested for the ability to displace [125I]iodosulpiride from human cloned Dopamine receptor D3, expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Columbia University College of Physicians and Surgeons

Curated by ChEMBL
LigandPNGBDBM50018958(CHEBI:75401 | QUINPIROLE)
Affinity DataKi:  260nMAssay Description:Displacement of [3H]Spiperone from human dopamine D2 long receptor expressed in CHO cells by competitive binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Columbia University College of Physicians and Surgeons

Curated by ChEMBL
LigandPNGBDBM50018958(CHEBI:75401 | QUINPIROLE)
Affinity DataKi:  260nMAssay Description:Displacement of [3H]spiperone from human D2L receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Columbia University College of Physicians and Surgeons

Curated by ChEMBL
LigandPNGBDBM50018958(CHEBI:75401 | QUINPIROLE)
Affinity DataKi:  260nMAssay Description:Displacement of [3H]spiperone from human dopamine D2L receptor transfected in CHO cells after 1 hr by scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Columbia University College of Physicians and Surgeons

Curated by ChEMBL
LigandPNGBDBM50018958(CHEBI:75401 | QUINPIROLE)
Affinity DataKi:  2.95E+3nMAssay Description:Displacement of [3H]N-methylspiperone from human D2 receptor transfected in HEK293 cells measured after 60 mins by liquid scintillation counterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(1A) dopamine receptor(Homo sapiens (Human))
Friedrich-Alexander University

Curated by ChEMBL
LigandPNGBDBM50018958(CHEBI:75401 | QUINPIROLE)
Affinity DataKi:  8.70E+3nMAssay Description:Displacement of [3H]SCH23390 from human D1 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(1A) dopamine receptor(Homo sapiens (Human))
Friedrich-Alexander University

Curated by ChEMBL
LigandPNGBDBM50018958(CHEBI:75401 | QUINPIROLE)
Affinity DataKi:  8.70E+3nMAssay Description:Displacement of [3H]SCH23390 from human dopamine D1 receptor transfected in HEK293 cells after 1 hr by scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Friedrich-Alexander University

Curated by ChEMBL
LigandPNGBDBM50018958(CHEBI:75401 | QUINPIROLE)
Affinity DataKi:  2.50E+4nMAssay Description:Displacement of [3H]ketanserin from human 5-HT2A receptor transfected in HEK293 cells by scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(1A) dopamine receptor(Homo sapiens (Human))
Friedrich-Alexander University

Curated by ChEMBL
LigandPNGBDBM50018958(CHEBI:75401 | QUINPIROLE)
Affinity DataKi:  8.70E+4nMAssay Description:Displacement of [3H]SCH23390 from human dopamine D1 receptor expressed in HEK293 cells by competitive binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-2 adrenergic receptor(Homo sapiens (Human))
Friedrich-Alexander University

Curated by ChEMBL
LigandPNGBDBM50018958(CHEBI:75401 | QUINPIROLE)
Affinity DataKi:  1.00E+5nMAssay Description:Displacement of [3H]CGP12177 from human beta2 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50018958(CHEBI:75401 | QUINPIROLE)
Affinity DataKi:  3.16E+5nMAssay Description:Binding affinity against Dopamine receptor D1 in rat striatal membranes using [3H]SCH-23390More data for this Ligand-Target Pair
In DepthDetails
TargetD(3) dopamine receptor(Homo sapiens (Human))
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50018958(CHEBI:75401 | QUINPIROLE)
Affinity DataEC50:  9.70nMAssay Description:Agonist activity at human dopamine D3 receptor transiently expressed in HEK293 cells co-expressing Galphao1 after 30 mins by [35S]GTPgammaS binding a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Columbia University College of Physicians and Surgeons

Curated by ChEMBL
LigandPNGBDBM50018958(CHEBI:75401 | QUINPIROLE)
Affinity DataEC50:  1.60E+3nMAssay Description:Agonist activity at human dopamine D2 short receptor transiently expressed in HEK293 cells co-expressing Galphai2 after 30 mins by [35S]GTPgammaS bin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Columbia University College of Physicians and Surgeons

Curated by ChEMBL
LigandPNGBDBM50018958(CHEBI:75401 | QUINPIROLE)
Affinity DataEC50:  680nMAssay Description:Agonist activity at D2 receptor (unknown origin) after 40 mins by [35S]GTP-gammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Columbia University College of Physicians and Surgeons

Curated by ChEMBL
LigandPNGBDBM50018958(CHEBI:75401 | QUINPIROLE)
Affinity DataEC50:  1.60E+3nMAssay Description:Intrinsic activity at human dopamine D2S receptor expressed in HEK293 cells co-transfected with Galpha0i assessed as [35S]GTPgammaS binding after 30 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Columbia University College of Physicians and Surgeons

Curated by ChEMBL
LigandPNGBDBM50018958(CHEBI:75401 | QUINPIROLE)
Affinity DataEC50:  2.30E+3nMAssay Description:Intrinsic activity at human dopamine D2S receptor expressed in HEK293 cells co-transfected with Galphai2 assessed as [35S]GTPgammaS binding after 30 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Columbia University College of Physicians and Surgeons

Curated by ChEMBL
LigandPNGBDBM50018958(CHEBI:75401 | QUINPIROLE)
Affinity DataEC50:  2.70E+3nMAssay Description:Intrinsic activity at human dopamine D2L receptor expressed in HEK293 cells co-transfected with Galpha0i assessed as [35S]GTPgammaS binding after 30 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Columbia University College of Physicians and Surgeons

Curated by ChEMBL
LigandPNGBDBM50018958(CHEBI:75401 | QUINPIROLE)
Affinity DataEC50:  2.80E+3nMAssay Description:Intrinsic activity at human dopamine D2L receptor expressed in HEK293 cells co-transfected with Galphai2 assessed as [35S]GTPgammaS binding after 30 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Columbia University College of Physicians and Surgeons

Curated by ChEMBL
LigandPNGBDBM50018958(CHEBI:75401 | QUINPIROLE)
Affinity DataEC50:  83nMAssay Description:Agonist activity at ARMS2-PK2-tagged human dopamine D2S receptor expressed in HEK293 cells co-expressing (EA)-tagged beta arrestin fusion protein ass...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Homo sapiens (Human))
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50018958(CHEBI:75401 | QUINPIROLE)
Affinity DataEC50:  10nMAssay Description:Activation of human dopamine D3 receptor L89K mutant expressed in HEK293 cells co-expressing GaqG66Di5- incubated for 120 mins by scintillation count...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Homo sapiens (Human))
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50018958(CHEBI:75401 | QUINPIROLE)
Affinity DataEC50:  2.40nMAssay Description:Activation of wild type human dopamine D3 receptor expressed in HEK293 cells co-expressing GaqG66Di5- incubated for 120 mins by scintillation countin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Columbia University College of Physicians and Surgeons

Curated by ChEMBL
LigandPNGBDBM50018958(CHEBI:75401 | QUINPIROLE)
Affinity DataEC50:  617nMAssay Description:Activity at dopamine D2S receptor (unknown origin) expressed in HEK293 cell membranes co-expressing Galpha protein subunit Galphao1 by [35S]GTPgammaS...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Columbia University College of Physicians and Surgeons

Curated by ChEMBL
LigandPNGBDBM50018958(CHEBI:75401 | QUINPIROLE)
Affinity DataEC50:  1.62E+3nMAssay Description:Activity at dopamine D2S receptor (unknown origin) expressed in HEK293 cell membranes co-expressing Galpha protein subunit Galphai2 by [35S]GTPgammaS...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Columbia University College of Physicians and Surgeons

Curated by ChEMBL
LigandPNGBDBM50018958(CHEBI:75401 | QUINPIROLE)
Affinity DataEC50:  51nMAssay Description:Activity at pro-link-tagged D2S-ARMS2PK2 (unknown origin) expressed in HEK293 cells by beta-arrestin-2 recruitment assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Columbia University College of Physicians and Surgeons

Curated by ChEMBL
LigandPNGBDBM50018958(CHEBI:75401 | QUINPIROLE)
Affinity DataEC50:  1.60nMAssay Description:Agonist activity at human D2S receptor expressed in HEK293 cells cotransfected with Gqi5 protein assessed as [3H]IP3 accumulation after 120 mins by s...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Columbia University College of Physicians and Surgeons

Curated by ChEMBL
LigandPNGBDBM50018958(CHEBI:75401 | QUINPIROLE)
Affinity DataEC50:  86nMAssay Description:Agonist activity at ARMS2-PK-tagged D2S receptor (unknown origin) transfected in HEK293 cells after 5 hrs by beta-arrestin assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Columbia University College of Physicians and Surgeons

Curated by ChEMBL
LigandPNGBDBM50018958(CHEBI:75401 | QUINPIROLE)
Affinity DataEC50:  8.20nMAssay Description:Agonist activity at recombinant human D2 receptor expressing in CHOp cells assessed as receptor mediated stimulation of mitogenesis measured as [3H]t...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Homo sapiens (Human))
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50018958(CHEBI:75401 | QUINPIROLE)
Affinity DataEC50:  3.30nMAssay Description:Agonist activity at recombinant human D3 receptor expressing in CHOp cells assessed as receptor mediated stimulation of mitogenesis measured as [3H]t...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(3) dopamine receptor(Homo sapiens (Human))
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50018958(CHEBI:75401 | QUINPIROLE)
Affinity DataEC50:  186nMAssay Description:Agonist activity at D3 receptor (unknown origin) expressed in cell membranes after 40 mins by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Columbia University College of Physicians and Surgeons

Curated by ChEMBL
LigandPNGBDBM50018958(CHEBI:75401 | QUINPIROLE)
Affinity DataEC50:  148nMAssay Description:Inhibitory constant against trypsin determined in VitroMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Columbia University College of Physicians and Surgeons

Curated by ChEMBL
LigandPNGBDBM50018958(CHEBI:75401 | QUINPIROLE)
Affinity DataEC50:  39nMAssay Description:Inhibitory constant against trypsin determined in VitroMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Columbia University College of Physicians and Surgeons

Curated by ChEMBL
LigandPNGBDBM50018958(CHEBI:75401 | QUINPIROLE)
Affinity DataEC50:  353nMAssay Description:Agonist activity at human dopamine D2 receptor expressed in HEK293 cells coexpressing renilla luciferase-fused Galphai1/GFP10-fused Ggamma2 by BRET a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Columbia University College of Physicians and Surgeons

Curated by ChEMBL
LigandPNGBDBM50018958(CHEBI:75401 | QUINPIROLE)
Affinity DataEC50:  11nMAssay Description:Agonist activity at human dopamine D2 receptor expressed in HEK293 cells assessed as cAMP inhibition by BRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Columbia University College of Physicians and Surgeons

Curated by ChEMBL
LigandPNGBDBM50018958(CHEBI:75401 | QUINPIROLE)
Affinity DataEC50:  270nMAssay Description:Agonist activity at human D2S receptor expressed in HEK293T cell membranes coexpressing Galphao1 assessed as induction of nucleotide exchange preincu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Columbia University College of Physicians and Surgeons

Curated by ChEMBL
LigandPNGBDBM50018958(CHEBI:75401 | QUINPIROLE)
Affinity DataEC50:  16nMAssay Description:Partial agonist activity at human D2SR expressed in HEK293T cells co-expressing (EA)beta-arrestin2 and GRK2 assessed as induction of beta-arrestin2 r...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Columbia University College of Physicians and Surgeons

Curated by ChEMBL
LigandPNGBDBM50018958(CHEBI:75401 | QUINPIROLE)
Affinity DataEC50:  52nMAssay Description:Partial agonist activity at human D2SR expressed in HEK293T cells co-expressing (EA)beta-arrestin2 assessed as induction of beta-arrestin2 recruitmen...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Columbia University College of Physicians and Surgeons

Curated by ChEMBL
LigandPNGBDBM50018958(CHEBI:75401 | QUINPIROLE)
Affinity DataEC50:  360nMAssay Description:Agonist activity at human D2SR expressed in HEK293 cell membranes co-expressing PTX insensitive variant of Galphao1 incubated for 30 mins by [35S]GTP...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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