BDBM50020471 CHEMBL3290142
SMILES Cc1ccc(NC(=O)c2cccc(c2)C(F)(F)F)cc1C(=O)Nc1cnc(Nc2cccc(NC(=O)C=C)c2)nc1
InChI Key InChIKey=BTWVWABAWDKQNJ-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 23 hits for monomerid = 50020471
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
University of Science and Technology of China
Curated by ChEMBL
University of Science and Technology of China
Curated by ChEMBL
Affinity DataKi: 27nMAssay Description:Reversible inhibition of full length recombinant human N-terminal His tagged BKT expressed in baculovirus infected Sf9 insect cells using poly (Glu,T...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
University of Science and Technology of China
Curated by ChEMBL
University of Science and Technology of China
Curated by ChEMBL
Affinity DataEC50: 24nMAssay Description:Inhibition of BTK in goat anti-human IgM antibody stimulated human Ramos cells assessed as PLCgamma2 phosphorylation preincubated for 1 hr followed b...More data for this Ligand-Target Pair
TargetCytoplasmic tyrosine-protein kinase BMX(Homo sapiens (Human))
Peking University
Curated by ChEMBL
Peking University
Curated by ChEMBL
Affinity DataIC50: 1.90nMAssay Description:Inhibition of Bmx (unknown origin) after 1 hr by HTRF assayMore data for this Ligand-Target Pair
Affinity DataIC50: 11nMAssay Description:Inhibition of EGFR (unknown origin) after 1 hr by HTRF assayMore data for this Ligand-Target Pair
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Peking University
Curated by ChEMBL
Peking University
Curated by ChEMBL
Affinity DataIC50: 19nMAssay Description:Inhibition of HER2 (unknown origin) after 1 hr by HTRF assayMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
University of Science and Technology of China
Curated by ChEMBL
University of Science and Technology of China
Curated by ChEMBL
Affinity DataIC50: 14nMAssay Description:Inhibition of Btk phosphorylation at Tyr551 in human Ramos cells after 1 hr by Western blot analysisMore data for this Ligand-Target Pair
TargetReceptor tyrosine-protein kinase erbB-4(Homo sapiens (Human))
Peking University
Curated by ChEMBL
Peking University
Curated by ChEMBL
Affinity DataIC50: 5.5nMAssay Description:Inhibition of HER4 (unknown origin) after 1 hr by HTRF assayMore data for this Ligand-Target Pair
Affinity DataIC50: >3.00E+4nMAssay Description:Inhibition of Itk (unknown origin) after 1 hr by HTRF assayMore data for this Ligand-Target Pair
Affinity DataIC50: 2.68E+3nMAssay Description:Inhibition of Jak3 (unknown origin) after 1 hr by HTRF assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.90nMAssay Description:Inhibition of Rlk (unknown origin) after 1 hr by HTRF assayMore data for this Ligand-Target Pair
Affinity DataIC50: 8.20nMAssay Description:Inhibition of Tec (unknown origin) after 1 hr by HTRF assayMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
University of Science and Technology of China
Curated by ChEMBL
University of Science and Technology of China
Curated by ChEMBL
Affinity DataIC50: 5nMAssay Description:Inhibition of Btk (unknown origin) after 1 hr by HTRF assayMore data for this Ligand-Target Pair
TargetCytoplasmic tyrosine-protein kinase BMX(Homo sapiens (Human))
Peking University
Curated by ChEMBL
Peking University
Curated by ChEMBL
Affinity DataIC50: 24nMAssay Description:Inhibition of full length recombinant human N-terminal GST-tagged BMX expressed in baculovirus infected Sf9 insect cells using poly (Glu,Tyr)4:1 as s...More data for this Ligand-Target Pair
Affinity DataIC50: 1.71E+3nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged JAK3 (781 to end residues) expressed in baculovirus infected Sf9 insect cells using poly (Glu,T...More data for this Ligand-Target Pair
Affinity DataIC50: 72nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged wild-type EGFR (695 to end residues) expressed in baculovirus infected Sf9 insect cells using p...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
University of Science and Technology of China
Curated by ChEMBL
University of Science and Technology of China
Curated by ChEMBL
Affinity DataIC50: 25nMAssay Description:Inhibition of full length recombinant human N-terminal His tagged BKT expressed in baculovirus infected Sf9 insect cells using poly (Glu,Tyr)4:1 as s...More data for this Ligand-Target Pair
Affinity DataIC50: 19nMAssay Description:Inhibition of wild type N-terminal GST tagged BLK (unknown origin) (1 to 505 residues) expressed in sf21 insect cell using TK as substrate incubated ...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
University of Science and Technology of China
Curated by ChEMBL
University of Science and Technology of China
Curated by ChEMBL
Affinity DataIC50: 21nMAssay Description:Inhibition of wild type N-terminal GST tagged BTK (unknown origin) (2 to 659 residues) expressed in sf21 insect cell using TK as substrate incubated ...More data for this Ligand-Target Pair
Affinity DataIC50: 15nMAssay Description:Inhibition of (S)-3-(3-(5-acrylamido-6-(3-(5-(2-methyl-5-(3-(trifluoromethyl)benzamido)benzamido)pyrimidin-2-ylamino)phenylamino)-6-oxohexylamino)-3-...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
University of Science and Technology of China
Curated by ChEMBL
University of Science and Technology of China
Curated by ChEMBL
Affinity DataIC50: 18nMAssay Description:Inhibition of (S)-3-(3-(5-acrylamido-6-(3-(5-(2-methyl-5-(3-(trifluoromethyl)benzamido)benzamido)pyrimidin-2-ylamino)phenylamino)-6-oxohexylamino)-3-...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
University of Science and Technology of China
Curated by ChEMBL
University of Science and Technology of China
Curated by ChEMBL
Affinity DataEC50: 18nMAssay Description:Inhibition of BTK in goat anti-human IgM antibody stimulated human Ramos cells assessed as BTK autophosphorylation at Tyr233 residue preincubated for...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
University of Science and Technology of China
Curated by ChEMBL
University of Science and Technology of China
Curated by ChEMBL
Affinity DataIC50: 8.5nMAssay Description:Inhibition of Btk in human Ramos cells assessed as inhibition of PLC-gamma2 phosphorylation at Tyr1217 after 1 hr by Western blot analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 2.70nMAssay Description:Inhibition of Blk (unknown origin) after 1 hr by HTRF assayMore data for this Ligand-Target Pair