BDBM50021620 CHEMBL3297764::US9145418, 26
SMILES CN1CCN(C[C@@H](NC(=O)C[C@H]2CNC(=O)c3cc(cn23)-c2cc(Cl)ccc2F)C2CCCCC2)CC1
InChI Key InChIKey=ZDZIFKRLEZXCII-WIOPSUGQSA-N
Data 4 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 4 hits for monomerid = 50021620
Affinity DataIC50: 2nMpH: 3.0Assay Description:Specific peptide or protein substrates are trans-phosphorylated by their specific ser-thr or tyr kinase in the presence of ATP traced with .sup.33P-....More data for this Ligand-Target Pair
Affinity DataIC50: 2nMAssay Description:Inhibition of human PIM1 using ARK-RERTYSFGHHA as substrate incubated for 60 mins prior to substrate addition by topcount scintillation counting anal...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase pim-2(Homo sapiens (Human))
Nerviano Medical Sciences
Curated by ChEMBL
Nerviano Medical Sciences
Curated by ChEMBL
Affinity DataIC50: 132nMAssay Description:Inhibition of human PIM2 using ARK-RERTYSFGHHA as substrate incubated for 60 mins prior to substrate addition by topcount scintillation counting anal...More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase pim-2(Homo sapiens (Human))
Nerviano Medical Sciences
Curated by ChEMBL
Nerviano Medical Sciences
Curated by ChEMBL
Affinity DataIC50: 132nMpH: 7.5Assay Description:Method for PIM2 Kinase Inhibition Assay: Dowex Techniquei. Kinase Buffer (KB)The buffer for PIM2 assay was composed of HEPES 50 mM, at pH 7.5, with 1...More data for this Ligand-Target Pair