BDBM50025159 CHEMBL3337869

SMILES COc1cccc(CNC(=O)c2nc3ccccc3c(=O)[nH]2)c1

InChI Key InChIKey=AARSEFXVCWMMKV-UHFFFAOYSA-N

Data  39 IC50

PDB links: 1 PDB ID matches this monomer.

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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50025159   

TargetStromelysin-1(Homo sapiens (Human))
Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50025159(CHEMBL3337869)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of APMA-activated recombinant human MMP-3 using Cy3-PLGLK(Cy5Q)AR-NH2 peptide as substrate measured after 40 mins by spectrofluorimetric m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50025159(CHEMBL3337869)
Affinity DataIC50:  300nMAssay Description:Inhibition of APMA-activated recombinant human MMP-2 using Cy3-PLGLK(Cy5Q)AR-NH2 peptide as substrate measured after 40 mins by spectrofluorimetric m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil collagenase(Homo sapiens (Human))
Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50025159(CHEMBL3337869)
Affinity DataIC50:  1.10E+3nMAssay Description:Inhibition of APMA-activated recombinant human MMP-8 using Cy3-PLGLK(Cy5Q)AR-NH2 peptide as substrate measured after 40 mins by spectrofluorimetric m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-2(Homo sapiens (Human))
Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50025159(CHEMBL3337869)
Affinity DataIC50:  3.40E+3nMAssay Description:Inhibition of APMA-activated recombinant human MMP-10 using Cy3-PLGLK(Cy5Q)AR-NH2 peptide as substrate measured after 40 mins by spectrofluorimetric ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50025159(CHEMBL3337869)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of APMA-activated recombinant human MMP-1 using Cy3-PLGLK(Cy5Q)AR-NH2 peptide as substrate measured after 40 mins by spectrofluorimetric m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrilysin(Homo sapiens (Human))
Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50025159(CHEMBL3337869)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of APMA-activated recombinant human MMP-7 using Cy3-PLGLK(Cy5Q)AR-NH2 peptide as substrate measured after 40 mins by spectrofluorimetric m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50025159(CHEMBL3337869)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of APMA-activated recombinant human MMP-9 using Cy3-PLGLK(Cy5Q)AR-NH2 peptide as substrate measured after 40 mins by spectrofluorimetric m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-14(Homo sapiens (Human))
Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50025159(CHEMBL3337869)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of APMA-activated recombinant human GST-tagged MMP-14 using Cy3-PLGLK(Cy5Q)AR-NH2 peptide as substrate measured after 40 mins by spectrofl...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDisintegrin and metalloproteinase domain-containing protein 17(Homo sapiens (Human))
Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50025159(CHEMBL3337869)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of TACE (unknown origin) using Cy3-PLAQAV(Cy5Q-L-2,3-diaminopropionic acid)-RSSSR-NH2 peptide as substrate measured after 40 mins by spect...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed