BDBM50026612 BIBF-1120::Nintedanib::US10981896, Compound Nintedanib::US11046672, Nintedanib::US11208381, Nintedanib::Vargatef
SMILES COC(=O)c1ccc2\C(=C(\Nc3ccc(cc3)N(C)C(=O)CN3CCN(C)CC3)c3ccccc3)C(=O)Nc2c1
InChI Key InChIKey=XZXHXSATPCNXJR-ZIADKAODSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 6 hits for monomerid = 50026612
TargetVascular endothelial growth factor receptor 1(Homo sapiens (Human))
Key Laboratory Of Structure-Based Drug Design And Discovery (Shenyang Pharmaceutical University)
Curated by ChEMBL
Key Laboratory Of Structure-Based Drug Design And Discovery (Shenyang Pharmaceutical University)
Curated by ChEMBL
Affinity DataIC50: 23nMAssay Description:Inhibition of recombinant human GST-tagged VEGFR1 cytoplasmic domain (781 to 1338 residues) expressed in baculovirus expression system preincubated f...More data for this Ligand-Target Pair
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
Key Laboratory Of Structure-Based Drug Design And Discovery (Shenyang Pharmaceutical University)
Curated by ChEMBL
Key Laboratory Of Structure-Based Drug Design And Discovery (Shenyang Pharmaceutical University)
Curated by ChEMBL
Affinity DataIC50: 3.70nMAssay Description:Inhibition of human N-terminal GST-tagged PDGFRbeta cytoplasmic domain (557 to 1106 residues) expressed in baculovirus expression system preincubated...More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Key Laboratory Of Structure-Based Drug Design And Discovery (Shenyang Pharmaceutical University)
Curated by ChEMBL
Key Laboratory Of Structure-Based Drug Design And Discovery (Shenyang Pharmaceutical University)
Curated by ChEMBL
Affinity DataIC50: 3.30nMAssay Description:Inhibition of human N-terminal GST-tagged VEGFR2 cytoplasmic domain (790 to 1356 residues) expressed in baculovirus expression system preincubated fo...More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 3(Homo sapiens (Human))
Key Laboratory Of Structure-Based Drug Design And Discovery (Shenyang Pharmaceutical University)
Curated by ChEMBL
Key Laboratory Of Structure-Based Drug Design And Discovery (Shenyang Pharmaceutical University)
Curated by ChEMBL
Affinity DataIC50: 3nMAssay Description:Inhibition of recombinant human GST-tagged VEGFR3 cytoplasmic domain expressed in baculovirus expression system preincubated for 10 mins followed by ...More data for this Ligand-Target Pair
TargetPlatelet-derived growth factor receptor alpha(Homo sapiens (Human))
Key Laboratory Of Structure-Based Drug Design And Discovery (Shenyang Pharmaceutical University)
Curated by ChEMBL
Key Laboratory Of Structure-Based Drug Design And Discovery (Shenyang Pharmaceutical University)
Curated by ChEMBL
Affinity DataIC50: 1.90nMAssay Description:Inhibition of PDGFRalpha (unknown origin) preincubated for 10 mins followed by FAM-labeled peptide substrate addition measured after 1 hr by mobility...More data for this Ligand-Target Pair
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
Key Laboratory Of Structure-Based Drug Design And Discovery (Shenyang Pharmaceutical University)
Curated by ChEMBL
Key Laboratory Of Structure-Based Drug Design And Discovery (Shenyang Pharmaceutical University)
Curated by ChEMBL
Affinity DataIC50: 99nMAssay Description:Inhibition of recombinant human GST-tagged FGFR1 cytoplasmic domain (398 to 822 residues) expressed in baculovirus expression system preincubated for...More data for this Ligand-Target Pair