BDBM50029763 5-(3,5-Diethoxy-4-pyrrol-1-yl-benzyl)-pyrimidine-2,4-diamine::CHEMBL280378::Epiroprim::TCMDC-137295

SMILES CCOc1cc(Cc2cnc(N)nc2N)cc(OCC)c1-n1cccc1

InChI Key InChIKey=NMARPFMJVCXSAV-UHFFFAOYSA-N

Data  6 KI  23 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50029763   

TargetDihydrofolate reductase(Homo sapiens (Human))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50029763(5-(3,5-Diethoxy-4-pyrrol-1-yl-benzyl)-pyrimidine-2...)
Affinity DataIC50:  200nMAssay Description:Concentration required to inhibit the human Dihydrofolate reductase by 50% was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50029763(5-(3,5-Diethoxy-4-pyrrol-1-yl-benzyl)-pyrimidine-2...)
Affinity DataIC50:  4.10nMAssay Description:Concentration required to inhibit the Mycobacterium avium Dihydrofolate reductase by 50% was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50029763(5-(3,5-Diethoxy-4-pyrrol-1-yl-benzyl)-pyrimidine-2...)
Affinity DataIC50:  6.00E+5nMAssay Description:Concentration required to inhibit the human Dihydrofolate reductase by 50% was determined (reported by Hoffman-LaRoche group)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50029763(5-(3,5-Diethoxy-4-pyrrol-1-yl-benzyl)-pyrimidine-2...)
Affinity DataIC50:  900nMAssay Description:Concentration required to inhibit the Toxoplasma gondii Dihydrofolate reductase by 50% was determined (reported by Hoffman-LaRoche group)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50029763(5-(3,5-Diethoxy-4-pyrrol-1-yl-benzyl)-pyrimidine-2...)
Affinity DataIC50:  3.00E+3nMAssay Description:Concentration required to inhibit the Pneumocystis carinii Dihydrofolate reductase by 50% was determined; Range : 2600-3000More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Rattus norvegicus (rat))
Harvard Medical School

Curated by ChEMBL
LigandPNGBDBM50029763(5-(3,5-Diethoxy-4-pyrrol-1-yl-benzyl)-pyrimidine-2...)
Affinity DataIC50:  160nMAssay Description:Concentration required to inhibit the rat liver Dihydrofolate reductase by 50% was determinedMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed