BDBM50033373 CHEMBL3357641

SMILES CN(C)C\C=C(/F)C(=O)Nc1cc2c(Nc3ccc(F)c(Cl)c3)ncnc2cc1O[C@H]1CCOC1

InChI Key InChIKey=HZBHTRUJNPPRNW-KAZCASEASA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50033373   

TargetCytochrome P450 2C19(Homo sapiens (Human))
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50033373(CHEMBL3357641)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CYP2C19 in human hepatic microsomes after 20 mins by LC/MS/MS methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 1A2(Homo sapiens (Human))
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50033373(CHEMBL3357641)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CYP1A2 in human hepatic microsomes after 20 mins by LC/MS/MS methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50033373(CHEMBL3357641)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CYP2C9 in human hepatic microsomes after 20 mins by LC/MS/MS methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50033373(CHEMBL3357641)
Affinity DataIC50:  149nMAssay Description:Inhibition of wild type HER2 (unknown origin) incubated for 5 mins by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50033373(CHEMBL3357641)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CYP3A4 in human hepatic microsomes after 20 mins by LC/MS/MS methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50033373(CHEMBL3357641)
Affinity DataIC50:  5.5nMAssay Description:Inhibition of wild type EGFR T790M mutant (unknown origin) incubated for 5 mins by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50033373(CHEMBL3357641)
Affinity DataIC50:  0.160nMAssay Description:Inhibition of wild type EGFR (unknown origin) incubated for 5 mins by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2D6(Homo sapiens (Human))
Zhejiang University

Curated by ChEMBL
LigandPNGBDBM50033373(CHEMBL3357641)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CYP2D6 in human hepatic microsomes after 20 mins by LC/MS/MS methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed