BDBM500339 (1''-Cyclopropyl-6''-hydroxy-8''-oxo-8''H-spiro[cyclohexane-1,5''-indolizine]-7''-carbonyl)glycine (52) and (2''-Cyclopropyl-6''-hydroxy-8''-oxo-8''H-spiro[cyclohexane-1,5''-indolizine]-7''-carbonyl)glycine (53)::US11021478, Example 52::US11021478, Example 53::US11655249, Example 53

SMILES OC(=O)CNC(=O)C1=C(O)C2(CCCCC2)n2ccc(C3CC3)c2C1=O

InChI Key InChIKey=ZQFNKGCKPGXZNZ-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 500339   

TargetEgl nine homolog 1(Homo sapiens (Human))
Kind Pharmaceutical

US Patent
LigandPNGBDBM500339((1''-Cyclopropyl-6''-hydroxy-8''-oxo-8''H-spiro[cy...)
Affinity DataIC50:  600nMAssay Description:Activities of HIF prolyl hydroxylase was determined according to the method as described in Anal Biochem, 2004, 330: 74-80, which was slightly modifi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEgl nine homolog 1(Homo sapiens (Human))
Kind Pharmaceutical

US Patent
LigandPNGBDBM500339((1''-Cyclopropyl-6''-hydroxy-8''-oxo-8''H-spiro[cy...)
Affinity DataIC50:  700nMAssay Description:1. Effect of Compounds on Activities of HIF Prolyl Hydroxylase-2 Activities of HIF prolyl hydroxylase was determined according to the method as descr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEgl nine homolog 1(Homo sapiens (Human))
Kind Pharmaceutical

US Patent
LigandPNGBDBM500339((1''-Cyclopropyl-6''-hydroxy-8''-oxo-8''H-spiro[cy...)
Affinity DataIC50:  600nMAssay Description:1. Effect of Compounds on Activities of HIF Prolyl Hydroxylase-2 Activities of HIF prolyl hydroxylase was determined according to the method as descr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetEgl nine homolog 1(Homo sapiens (Human))
Kind Pharmaceutical

US Patent
LigandPNGBDBM500339((1''-Cyclopropyl-6''-hydroxy-8''-oxo-8''H-spiro[cy...)
Affinity DataIC50:  700nMAssay Description:Activities of HIF prolyl hydroxylase was determined according to the method as described in Anal Biochem, 2004, 330: 74-80, which was slightly modifi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent