BDBM50036681 (E)-2-Cyano-3-[3-(4,5-dihydro-thiazol-2-ylsulfanylmethyl)-4-hydroxy-5-methoxy-phenyl]-acrylamide::2-Cyano-3-[3-(4,5-dihydro-thiazol-2-ylsulfanylmethyl)-4-hydroxy-5-methoxy-phenyl]-acrylamide::CHEMBL324030

SMILES COc1cc(\C=C(/C#N)C(N)=O)cc(CSC2=NCCS2)c1O

InChI Key InChIKey=AEZUIGRHDSRYGK-ONNFQVAWSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50036681   

TargetEpidermal growth factor receptor/Receptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Hebrew University Of Jerusalem

Curated by ChEMBL
LigandPNGBDBM50036681((E)-2-Cyano-3-[3-(4,5-dihydro-thiazol-2-ylsulfanyl...)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of HER-14 (human EGFR overexpressing NIH3T3) cell proliferationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Hebrew University Of Jerusalem

Curated by ChEMBL
LigandPNGBDBM50036681((E)-2-Cyano-3-[3-(4,5-dihydro-thiazol-2-ylsulfanyl...)
Affinity DataIC50:  8.80E+3nMAssay Description:Inhibitiory concentration against EGF receptor by autophosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Hebrew University Of Jerusalem

Curated by ChEMBL
LigandPNGBDBM50036681((E)-2-Cyano-3-[3-(4,5-dihydro-thiazol-2-ylsulfanyl...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of HER-14 (human EGFR overexpressing NIH3T3) cell proliferationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Hebrew University Of Jerusalem

Curated by ChEMBL
LigandPNGBDBM50036681((E)-2-Cyano-3-[3-(4,5-dihydro-thiazol-2-ylsulfanyl...)
Affinity DataIC50:  8.71E+3nMAssay Description:Inhibitory activity against epidermal growth factor receptor (EGFR)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Hebrew University Of Jerusalem

Curated by ChEMBL
LigandPNGBDBM50036681((E)-2-Cyano-3-[3-(4,5-dihydro-thiazol-2-ylsulfanyl...)
Affinity DataIC50:  1.63E+4nMAssay Description:Inhibitiory concentration against EGF receptor by polyGAT phosphorylationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
University Of Tennessee Health Sciences Center

Curated by ChEMBL
LigandPNGBDBM50036681((E)-2-Cyano-3-[3-(4,5-dihydro-thiazol-2-ylsulfanyl...)
Affinity DataIC50:  8.71E+3nMAssay Description:Inhibitory activity tested against protein kinase HER-2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed