BDBM500370 4-(6-methoxy- 1H-indol-3- yl)-7-[[5-(4- methylpiperazin- 1-yl)-2- pyridyl]amino] isoindolin-1-one::US11021481, Compound I-28::US11078201, Compound I-28::US11548890, Compound I-28

SMILES COc1ccc2c(c[nH]c2c1)-c1ccc(Nc2ccc(cn2)N2CCN(C)CC2)c2C(=O)NCc12

InChI Key InChIKey=NGSAGMQVLJTCGF-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 500370   

TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Nimbus Saturn

US Patent
LigandPNGBDBM500370(4-(6-methoxy- 1H-indol-3- yl)-7-[[5-(4- methylpipe...)
Affinity DataIC50: <100nMAssay Description:HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Nimbus Saturn

US Patent
LigandPNGBDBM500370(4-(6-methoxy- 1H-indol-3- yl)-7-[[5-(4- methylpipe...)
Affinity DataIC50: <100nMAssay Description:HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Nimbus Saturn

US Patent
LigandPNGBDBM500370(4-(6-methoxy- 1H-indol-3- yl)-7-[[5-(4- methylpipe...)
Affinity DataIC50: <100nMAssay Description:HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Nimbus Saturn

US Patent
LigandPNGBDBM500370(4-(6-methoxy- 1H-indol-3- yl)-7-[[5-(4- methylpipe...)
Affinity DataIC50: <100nMAssay Description:HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase kinase kinase kinase 1(Homo sapiens (Human))
Nimbus Saturn

US Patent
LigandPNGBDBM500370(4-(6-methoxy- 1H-indol-3- yl)-7-[[5-(4- methylpipe...)
Affinity DataIC50: <100nMAssay Description:HPK1 biochemical enzyme assay: HPK1 enzyme inhibition was measured using a microfluidic mobility shift assay. Reactions were performed in a 384-well ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent