BDBM50039233 1-{2-[9-(4-Methoxy-phenyl)-9H-fluoren-9-yloxy]-ethyl}-piperidine-3-carboxylic acid::CHEMBL75800

SMILES COc1ccc(cc1)C1(OCCN2CCCC(C2)C(O)=O)c2ccccc2-c2ccccc12

InChI Key InChIKey=PDWYUQWCERDHRZ-UHFFFAOYSA-N

Data  12 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 12 hits for monomerid = 50039233   

TargetSodium- and chloride-dependent GABA transporter 2(Rattus norvegicus)
Synaptic Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50039233(1-{2-[9-(4-Methoxy-phenyl)-9H-fluoren-9-yloxy]-eth...)
Affinity DataIC50:  5.10E+4nMAssay Description:Inhibitory activity against rat GABA transporter-2 (rGAT2)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent GABA transporter 1(Homo sapiens (Human))
Synaptic Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50039233(1-{2-[9-(4-Methoxy-phenyl)-9H-fluoren-9-yloxy]-eth...)
Affinity DataIC50:  1.33E+5nMAssay Description:Inhibitory activity against human GABA transporter-1 (hGAT1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent GABA transporter 3(Homo sapiens (Human))
Synaptic Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50039233(1-{2-[9-(4-Methoxy-phenyl)-9H-fluoren-9-yloxy]-eth...)
Affinity DataIC50:  1.42E+5nMAssay Description:Inhibitory activity against human sodium and chloride dependent GABA transporter 3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent GABA transporter 1(Homo sapiens (Human))
Synaptic Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50039233(1-{2-[9-(4-Methoxy-phenyl)-9H-fluoren-9-yloxy]-eth...)
Affinity DataIC50:  1.32E+5nMAssay Description:Inhibition of human GAT1-mediated GABA uptakeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent GABA transporter 2(Rattus norvegicus)
Synaptic Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50039233(1-{2-[9-(4-Methoxy-phenyl)-9H-fluoren-9-yloxy]-eth...)
Affinity DataIC50:  5.10E+4nMAssay Description:Inhibition of rat GAT2-mediated GABA uptakeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent GABA transporter 2(Rattus norvegicus)
Synaptic Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50039233(1-{2-[9-(4-Methoxy-phenyl)-9H-fluoren-9-yloxy]-eth...)
Affinity DataIC50:  5.10E+4nMAssay Description:Inhibition of rat GAT-2 expressed in thymidine kinase deficient mouse LM cells assessed as decrease in [3H]GABA uptake after 10 mins by scintillation...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent GABA transporter 2(Mus musculus)
Ludwig-Maximilians-Universit£T M£Nchen

Curated by ChEMBL
LigandPNGBDBM50039233(1-{2-[9-(4-Methoxy-phenyl)-9H-fluoren-9-yloxy]-eth...)
Affinity DataIC50:  9.33E+4nMAssay Description:Inhibition of mouse GAT3 expressed in HEK293 cells assessed as decrease in [3H]GABA uptake preincubated for 25 mins followed by [3H]GABA addition mea...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent GABA transporter 3(Mus musculus)
Ludwig-Maximilians-Universit£T M£Nchen

Curated by ChEMBL
LigandPNGBDBM50039233(1-{2-[9-(4-Methoxy-phenyl)-9H-fluoren-9-yloxy]-eth...)
Affinity DataIC50:  3.02E+4nMAssay Description:Inhibition of mouse GAT4 expressed in HEK293 cells assessed as decrease in [3H]GABA uptake preincubated for 25 mins followed by [3H]GABA addition mea...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent GABA transporter 1(Homo sapiens (Human))
Synaptic Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50039233(1-{2-[9-(4-Methoxy-phenyl)-9H-fluoren-9-yloxy]-eth...)
Affinity DataIC50:  1.33E+5nMAssay Description:Inhibition of human GAT-1 expressed in thymidine kinase deficient mouse LM cells assessed as decrease in [3H]GABA uptake after 10 mins by scintillati...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent betaine transporter(Homo sapiens (Human))
Ludwig-Maximilians-Universit£T M£Nchen

Curated by ChEMBL
LigandPNGBDBM50039233(1-{2-[9-(4-Methoxy-phenyl)-9H-fluoren-9-yloxy]-eth...)
Affinity DataIC50:  2.70E+4nMAssay Description:Inhibition of human BGT-1 expressed in thymidine kinase deficient mouse LM cells assessed as decrease in [3H]GABA uptake after 10 mins by scintillati...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent GABA transporter 3(Homo sapiens (Human))
Synaptic Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50039233(1-{2-[9-(4-Methoxy-phenyl)-9H-fluoren-9-yloxy]-eth...)
Affinity DataIC50:  1.42E+5nMAssay Description:Inhibition of human GAT-3 expressed in thymidine kinase deficient mouse LM cells assessed as decrease in [3H]GABA uptake after 10 mins by scintillati...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium- and chloride-dependent GABA transporter 3(Homo sapiens (Human))
Synaptic Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50039233(1-{2-[9-(4-Methoxy-phenyl)-9H-fluoren-9-yloxy]-eth...)
Affinity DataIC50:  1.42E+5nMAssay Description:Inhibition of human GAT3-mediated GABA uptakeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed