BDBM50041178 5-((3,4-dichlorophenylamino)methyl)furo[2,3-d]pyrimidine-2,4-diamine::5-[(3,4-Dichloro-phenylamino)-methyl]-furo[2,3-d]pyrimidine-2,4-diamine::CHEMBL274278

SMILES Nc1nc(N)c2c(CNc3ccc(Cl)c(Cl)c3)coc2n1

InChI Key InChIKey=IQXPYLVUVFJOHY-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50041178   

TargetDihydrofolate reductase(Pneumocystis carinii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50041178(5-((3,4-dichlorophenylamino)methyl)furo[2,3-d]pyri...)
Affinity DataIC50: >3.50E+4nMAssay Description:Inhibitory concentration of the compound for DHFR in Pneumocystis cariniiMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50041178(5-((3,4-dichlorophenylamino)methyl)furo[2,3-d]pyri...)
Affinity DataIC50: >1.50E+4nMAssay Description:Inhibitory concentration of the compound for DHFR in recombinant humanMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50041178(5-((3,4-dichlorophenylamino)methyl)furo[2,3-d]pyri...)
Affinity DataIC50:  8.93E+4nMAssay Description:Inhibitory concentration of the compound for DHFR in Toxoplasma gondiiMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50041178(5-((3,4-dichlorophenylamino)methyl)furo[2,3-d]pyri...)
Affinity DataIC50:  8.93E+4nMAssay Description:Inhibition of Toxoplasma gondii DHFR by spectrophotometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Rattus norvegicus (rat))
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50041178(5-((3,4-dichlorophenylamino)methyl)furo[2,3-d]pyri...)
Affinity DataIC50:  3.52E+4nMAssay Description:Inhibitory concentration of the compound for DHFR in rat liverMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Rattus norvegicus (rat))
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50041178(5-((3,4-dichlorophenylamino)methyl)furo[2,3-d]pyri...)
Affinity DataIC50:  3.52E+4nMAssay Description:Inhibition of rat liver DHFR by spectrophotometric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Lactobacillus casei)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50041178(5-((3,4-dichlorophenylamino)methyl)furo[2,3-d]pyri...)
Affinity DataIC50: >3.00E+3nMAssay Description:Inhibitory concentration of the compound for DHFR in Lactobacillus caseiMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed