BDBM50041978 CHEMBL3134157
SMILES Cc1cc(CS(=O)(=O)c2ccccc2)cc(OCc2ccc(CN3CCC[C@@H]3CO)cc2)c1
InChI Key InChIKey=NPUXORBZRBIOMQ-RUZDIDTESA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 57 hits for monomerid = 50041978
Affinity DataKi: 3.60nMAssay Description:Inhibition of human C-terminal His6-tagged SphK1 expressed in baculovirus infected Sf21 insect cellsMore data for this Ligand-Target Pair
3D Structure (crystal)Affinity DataKi: 3.60nMAssay Description:Competitive inhibition of recombinant human C-terminal His-tagged SphK1 expressed in baculovirus infected Sf21 cells using varying concentrations of ...More data for this Ligand-Target Pair
Affinity DataKi: 3.60nMAssay Description:Competitive-inhibition of recombinant human C-terminal His6-tagged Sphk1 expressed in baculovirus infected Sf21 insect cells using varying levels of ...More data for this Ligand-Target Pair
Affinity DataKi: 3.60nMAssay Description:Inhibition of SK2 (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: 3.60nMAssay Description:Inhibition of recombinant human SphK1 expressed in baculovirus infected Sf9 cells assessed as decrease in [33P]SIP production using D-erythro-sphingo...More data for this Ligand-Target Pair
Affinity DataKi: 3.60nMAssay Description:Inhibition of recombinant human C-terminal His-tagged SPHK1 expressed in fall armyworm sf21 cells using sphingosine as substrate after 1 hr by FITC-b...More data for this Ligand-Target Pair
Affinity DataKi: 3.60nMAssay Description:Inhibition of human recombinant SphK1 expressed in Sf9 cells assessed as radiolabeled products using 5 uM sphingosine and 10 uM gamma[32P]ATP by liqu...More data for this Ligand-Target Pair
Affinity DataKi: 3.60nMAssay Description:Inhibition of SphK1 in mouse erythrocytes using sphingosine as substrate by luminescence assayMore data for this Ligand-Target Pair
Affinity DataKi: 4nMAssay Description:Inhibition of SK1 (unknown origin) using 5 uM of sphingosine as substrateMore data for this Ligand-Target Pair
Affinity DataKi: 4.30nMAssay Description:Inhibition of His6 tagged human SphK1 expressed in Sf21 cells using FITC-sphingosine as substrate preincubated for 90 mins prior substrate addition b...More data for this Ligand-Target Pair
Affinity DataIC50: 2.70nMAssay Description:Inhibition of recombinant C-terminal His6-tagged human SphK1 expressed in baculovirus infected sf21 cells using FITC-sphingosine as substrate after 1...More data for this Ligand-Target Pair
Affinity DataIC50: 360nMAssay Description:Inhibition of human recombinant C-terminal His6 tagged SphK2 expressed in baculovirus infected sf21 cells using FITC-sphingosine as substrate after 1...More data for this Ligand-Target Pair
Affinity DataIC50: 28nMAssay Description:Inhibition of recombinant SK1 (unknown origin) using sphingosine and [gamma-32P]ATP as substrate after 30 minsMore data for this Ligand-Target Pair
Affinity DataKd: 5nMAssay Description:Binding affinity to SK1 (unknown origin) assessed as inhibition of sphingosine phosphorylationMore data for this Ligand-Target Pair
Affinity DataIC50: 28nMAssay Description:Inhibition of GFP-tagged SK1 (unknown origin) expressed in HEK293 cells using Sph as substrate measured after 30 mins in presence of [gamma32P]ATP by...More data for this Ligand-Target Pair
Affinity DataIC50: >5.00E+3nMAssay Description:Inhibition of recombinant human full-length N-terminal His-tagged SK2 expressed in baculovirus infected Sf9 insect cells using Sph as substrate measu...More data for this Ligand-Target Pair
Affinity DataIC50: 40nMAssay Description:Inhibition of SphK1 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 5.40E+3nMAssay Description:Inhibition of SphK2 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 356nMAssay Description:Antagonistic activity against (-)-phenylephrine-induced contraction of rat spleen (Alpha-1B adrenergic receptor )More data for this Ligand-Target Pair
Affinity DataIC50: 2.60nMAssay Description:Inhibition of SPHK1 (unknown origin) using sphingosine-fluorescein as substrate incubated for 1 hr in presence of ATP by mobility shift assayMore data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 1(Human)
China Pharmaceutical University
Curated by ChEMBL
China Pharmaceutical University
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of VEGFR1 (unknown origin)More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Human)
China Pharmaceutical University
Curated by ChEMBL
China Pharmaceutical University
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of VEGFR2 (unknown origin)More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 3(Human)
China Pharmaceutical University
Curated by ChEMBL
China Pharmaceutical University
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of VEGFR3 (unknown origin)More data for this Ligand-Target Pair
TargetPlatelet-derived growth factor receptor alpha(Human)
China Pharmaceutical University
Curated by ChEMBL
China Pharmaceutical University
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of PDGFRalpha (unknown origin)More data for this Ligand-Target Pair
TargetPlatelet-derived growth factor receptor beta(Human)
China Pharmaceutical University
Curated by ChEMBL
China Pharmaceutical University
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of PDGFRbeta (unknown origin)More data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Human)
China Pharmaceutical University
Curated by ChEMBL
China Pharmaceutical University
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of RET (unknown origin)More data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Human)
China Pharmaceutical University
Curated by ChEMBL
China Pharmaceutical University
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of FLT3 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of EGFR (unknown origin)More data for this Ligand-Target Pair
TargetReceptor tyrosine-protein kinase erbB-2(Human)
China Pharmaceutical University
Curated by ChEMBL
China Pharmaceutical University
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of ERBB2 (unknown origin)More data for this Ligand-Target Pair
TargetReceptor tyrosine-protein kinase erbB-4(Human)
China Pharmaceutical University
Curated by ChEMBL
China Pharmaceutical University
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of ERBB4 (unknown origin)More data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase Src(Human)
China Pharmaceutical University
Curated by ChEMBL
China Pharmaceutical University
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of SRC (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of ABL (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of EPHA2 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of EPHB2 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of ACK1 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of IGF1R (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of Insulin receptor (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of FGFR1 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of FGFR2 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of FGFR3 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of FGFR4 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of BTK (unknown origin)More data for this Ligand-Target Pair
TargetMacrophage colony-stimulating factor 1 receptor(Human)
China Pharmaceutical University
Curated by ChEMBL
China Pharmaceutical University
Curated by ChEMBL
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of CSF1R (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 3.60nMAssay Description:Inhibition of C-terminal His6-tagged human SPHK1 expressed in baculovirus infected Sf21 insect cells using FITC-sphingosine as substrate preincubated...More data for this Ligand-Target Pair
Affinity DataIC50: >5.00E+3nMAssay Description:Inhibition of SPHK2 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 2.70nMAssay Description:Antagonistic activity against (-)-noradrenaline-induced contraction of rat thoracic aorta (Alpha-1D adrenergic receptor)More data for this Ligand-Target Pair
Affinity DataIC50: 20nMAssay Description:Inhibition of SPHK1 in human whole-blood using C17-sphingosine as substrate assessed as reduction in C17-S1P production preincubated for 30 mins foll...More data for this Ligand-Target Pair
Affinity DataIC50: 2.70nMAssay Description:Effective concentration for human progesterone receptor in T47D human breast cancer cellMore data for this Ligand-Target Pair
Affinity DataIC50: 2nMAssay Description:Inhibition of human C-terminal His6-tagged SPHK1 expressed in fall armyworm sf9 cells assessed as reduction in ADP formation using sphingosine as sub...More data for this Ligand-Target Pair
Affinity DataIC50: 0.800nMAssay Description:Inhibition of SPHK1 in human MDA1483 cells using C17-sphingosine as substrate assessed as reduction in C17-S1P formation preincubated for 30 mins wit...More data for this Ligand-Target Pair