BDBM50042874 2,2'-Bipyridin::2,2'-bipyridine::2,2'-bipyridyl::2,2'-dipyridine::2,2'-dipyridyl::2-(2-pyridyl)pyridine::CHEMBL39879::US10196346, Bipyridine::alpha,alpha'-bipyridine::alpha,alpha'-bipyridyl::alpha,alpha'-dipyridine::alpha,alpha'-dipyridyl::bpy

SMILES c1ccc(nc1)-c1ccccn1

InChI Key InChIKey=ROFVEXUMMXZLPA-UHFFFAOYSA-N

Data  7 IC50  10 EC50

PDB links: 2 PDB IDs match this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 17 hits for monomerid = 50042874   

TargetTransmembrane prolyl 4-hydroxylase(Homo sapiens (Human))
Zeneca Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50042874(2,2'-Bipyridin | 2,2'-bipyridine | 2,2'-bipyridyl ...)
Affinity DataIC50:  3.42E+4nMAssay Description:Inhibition of prolyl 4-hydroxylase by chromatographic determination of [14C]-succinic acid on ion-exchange minicolumnaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDeoxyhypusine hydroxylase(Homo sapiens)
China Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50042874(2,2'-Bipyridin | 2,2'-bipyridine | 2,2'-bipyridyl ...)
Affinity DataIC50:  5.00E+3nMAssay Description:Inhibition of DOHH (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMethionine aminopeptidase 1(Homo sapiens (Human))
Johns Hopkins University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50042874(2,2'-Bipyridin | 2,2'-bipyridine | 2,2'-bipyridyl ...)
Affinity DataEC50:  320nMAssay Description:Inhibition of human methionine aminopeptidase 1 in presence of Co2+More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMethionine aminopeptidase 1(Homo sapiens (Human))
Johns Hopkins University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50042874(2,2'-Bipyridin | 2,2'-bipyridine | 2,2'-bipyridyl ...)
Affinity DataEC50: >1.00E+5nMAssay Description:Inhibition of human methionine aminopeptidase 1 in presence of Zn2+More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMethionine aminopeptidase 1(Homo sapiens (Human))
Johns Hopkins University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50042874(2,2'-Bipyridin | 2,2'-bipyridine | 2,2'-bipyridyl ...)
Affinity DataEC50: >1.00E+5nMAssay Description:Inhibition of human methionine aminopeptidase 1 in presence of Mn2+More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50042874(2,2'-Bipyridin | 2,2'-bipyridine | 2,2'-bipyridyl ...)
Affinity DataEC50:  2.00E+4nMAssay Description:Allosteric modulation at human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as [3H]IP3 turnover by liquid scintillation coun...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 1(Homo sapiens (Human))
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50042874(2,2'-Bipyridin | 2,2'-bipyridine | 2,2'-bipyridyl ...)
Affinity DataEC50:  3.16E+4nMAssay Description:Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation coun...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 8(Homo sapiens (Human))
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50042874(2,2'-Bipyridin | 2,2'-bipyridine | 2,2'-bipyridyl ...)
Affinity DataEC50:  4.20E+4nMAssay Description:Allosteric modulation at human CCR8 transfected in COS7 cells assessed as [3H]IP3 turnover by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50042874(2,2'-Bipyridin | 2,2'-bipyridine | 2,2'-bipyridyl ...)
Affinity DataIC50:  8.40E+4nMAssay Description:Displacement of [125I]-CCL3 from human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr after 3 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 1(Homo sapiens (Human))
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50042874(2,2'-Bipyridin | 2,2'-bipyridine | 2,2'-bipyridyl ...)
Affinity DataEC50:  3.40E+4nMAssay Description:Allosteric modulation at human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as {3H]IP3 turnover by liquid scintillation coun...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50042874(2,2'-Bipyridin | 2,2'-bipyridine | 2,2'-bipyridyl ...)
Affinity DataIC50:  7.94E+4nMAssay Description:Displacement of [125I]-CCL3 from human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr after 3 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 1(Homo sapiens (Human))
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50042874(2,2'-Bipyridin | 2,2'-bipyridine | 2,2'-bipyridyl ...)
Affinity DataIC50:  1.26E+5nMAssay Description:Displacement of [125I]-CCL3 from human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr after 3 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 1(Homo sapiens (Human))
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50042874(2,2'-Bipyridin | 2,2'-bipyridine | 2,2'-bipyridyl ...)
Affinity DataIC50:  1.26E+5nMAssay Description:Displacement of [125I]-CCL3 from human CCR1 transfected in COS7 cells coexpressing chimeric Gqi4myr after 3 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 5(Homo sapiens (Human))
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50042874(2,2'-Bipyridin | 2,2'-bipyridine | 2,2'-bipyridyl ...)
Affinity DataEC50:  1.90E+4nMAssay Description:Allosteric modulation at human CCR5 transfected in COS7 cells coexpressing chimeric Gqi4myr assessed as [3H]IP3 turnover by liquid scintillation coun...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetC-C chemokine receptor type 8(Homo sapiens (Human))
University Of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50042874(2,2'-Bipyridin | 2,2'-bipyridine | 2,2'-bipyridyl ...)
Affinity DataEC50:  3.98E+4nMAssay Description:Allosteric modulation at human CCR8 transfected in COS7 cells assessed as [3H]IP3 turnover by liquid scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHypoxia-inducible factor 1-alpha(Homo sapiens (Human))
Institute of Pharmacology and Toxicology Academy of Military Medical Sciences P.L.A. China

US Patent
LigandPNGBDBM50042874(2,2'-Bipyridin | 2,2'-bipyridine | 2,2'-bipyridyl ...)
Affinity DataEC50:  4.14E+4nMAssay Description:The compounds were formulated with DMSO to form 30 mM stock solutions, and then formulated with analytical nutrient solution to form 2× working solut...More data for this Ligand-Target Pair
In DepthDetails US Patent
LigandPNGBDBM50042874(2,2'-Bipyridin | 2,2'-bipyridine | 2,2'-bipyridyl ...)
Affinity DataIC50:  1.00E+8nMAssay Description:Inhibition of [3H]-farnesyl pyrophosphate binding to human farnesyltransferaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed