BDBM50042928 CHEMBL3354567::US9512126, 13

SMILES COc1ccc(cc1F)C(=O)c1cc(NCCC(F)(F)F)c2ncc(-c3ccc(C(=O)NC4CC4)c(C)c3)n2n1

InChI Key InChIKey=WVPNNDAQCJXQPT-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50042928   

TargetDual specificity protein kinase TTK(Homo sapiens (Human))
Dart Neuroscience

Curated by ChEMBL
LigandPNGBDBM50042928(CHEMBL3354567 | US9512126, 13)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of Mps1 (unknown origin) activity by TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity protein kinase TTK/Glutathione S-transferase P(Homo sapiens (Human))
Bayer Intellectual Property

US Patent
LigandPNGBDBM50042928(CHEMBL3354567 | US9512126, 13)
Affinity DataIC50:  0.400nMpH: 7.7 T: 2°CAssay Description:The human kinase Mps-1 phosphorylates a biotinylated substrate peptide. Detection of the phosphorylated product is achieved by time-resolved fluoresc...More data for this Ligand-Target Pair
In DepthDetails US Patent