BDBM50043290 CHEMBL3355038

SMILES COc1cc2ncnc(Nc3ccc4N(CCc4c3)C(=O)Cc3c(C)[nH]c4cc(F)ccc34)c2cc1OC

InChI Key InChIKey=NEWVPRAIGYZHJF-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50043290   

TargetEukaryotic translation initiation factor 2-alpha kinase 3(Homo sapiens (Human))
Dart Neuroscience

Curated by ChEMBL
LigandPNGBDBM50043290(CHEMBL3355038)
Affinity DataIC50:  25nMAssay Description:Inhibition of PERK (unknown origin) expressed in HEK293 cells assessed as inhibition of phosphorylation of GFP-eIF2 alpha by cell-based TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEukaryotic translation initiation factor 2-alpha kinase 3(Homo sapiens (Human))
Dart Neuroscience

Curated by ChEMBL
LigandPNGBDBM50043290(CHEMBL3355038)
Affinity DataIC50:  0.631nMAssay Description:Inhibition of recombinant GST-tagged PERK (unknown origin) by LanthaScreen assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed