BDBM50043693 CHEMBL3355541::US10047093, 8-67::US10392392, Example 8-67::US10875864, EX. 8-67::US9416132, 8-67

SMILES CN1CCC(CNc2ccn3ncc(-c4cccc(OC(F)(F)F)c4)c3n2)CC1

InChI Key InChIKey=RXIOLPKAVOQIOE-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50043693   

TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
Tolero Pharmaceuticals

US Patent
LigandPNGBDBM50043693(CHEMBL3355541 | US10047093, 8-67 | US10392392, Exa...)
Affinity DataIC50:  45nMT: 2°CAssay Description:These assays are set up in duplicate 50 ul volumes in white, flat bottom 96 well plates. Inhibitors are added to the solution of 1× kinase buff...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
Tolero Pharmaceuticals

US Patent
LigandPNGBDBM50043693(CHEMBL3355541 | US10047093, 8-67 | US10392392, Exa...)
Affinity DataIC50:  45nMAssay Description:Inhibition of Pim1 (unknown origin) using luciferase-luciferin based ATP detection reagent by Kinase-Glo assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50043693(CHEMBL3355541 | US10047093, 8-67 | US10392392, Exa...)
Affinity DataIC50:  1.90E+3nMAssay Description:Inhibition of human ERG expressed in CHO cells by automated patch clamp methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
Tolero Pharmaceuticals

US Patent
LigandPNGBDBM50043693(CHEMBL3355541 | US10047093, 8-67 | US10392392, Exa...)
Affinity DataIC50:  45nMAssay Description:One illustrative manner in which Pim-1 kinase activity can be determined is by quantifying the amount of ATP remaining in solution after an in vitro ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
Tolero Pharmaceuticals

US Patent
LigandPNGBDBM50043693(CHEMBL3355541 | US10047093, 8-67 | US10392392, Exa...)
Affinity DataIC50:  45nMT: 2°CAssay Description:One illustrative manner in which Pim-1 kinase activity can be determined is by quantifying the amount of ATP remaining in solution after an in vitro ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
Tolero Pharmaceuticals

US Patent
LigandPNGBDBM50043693(CHEMBL3355541 | US10047093, 8-67 | US10392392, Exa...)
Affinity DataIC50:  45nMAssay Description:One illustrative manner in which Pim-1 kinase activity can be determined is by quantifying the amount of ATP remaining in solution after an in vitro ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSerine/threonine-protein kinase pim-2(Homo sapiens (Human))
Astex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50043693(CHEMBL3355541 | US10047093, 8-67 | US10392392, Exa...)
Affinity DataIC50:  1.49E+3nMAssay Description:Inhibition of Pim2 (unknown origin) using luciferase-luciferin based ATP detection reagent by Kinase-Glo assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed