BDBM50043705 CHEMBL3356002

SMILES Cc1cc(Nc2nc3ccccc3[nH]2)c2ccccc2c1Oc1ncccc1-c1ccnc(N[C@H]2CCCNC2)n1

InChI Key InChIKey=UMVDHPFXGXTJAT-NRFANRHFSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50043705   

TargetMitogen-activated protein kinase 10(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50043705(CHEMBL3356002)
Affinity DataIC50:  20nMAssay Description:Inhibition of human wild type JNK3 using biotinylated ATF2 substrate assessed as phosphorylation at thr53 on ATF2 by fluorescent plate readerMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase/endoribonuclease IRE1(Homo sapiens (Human))
Amgen

Curated by ChEMBL
LigandPNGBDBM50043705(CHEMBL3356002)
Affinity DataIC50:  5.10nMAssay Description:Inhibition of human IRE1alpha using 5'[6FAM]-GAGUCCGCAGCACUC-[BHQ1]3' substrate by biochemical fluorescence quenching assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed