BDBM50044068 CHEMBL15904::N-[5-(3,5-Di-tert-butyl-4-hydroxy-benzylidene)-1-methyl-4-oxo-4,5-dihydro-1H-imidazol-2-yl]-guanidine::N-{5-[1-(3,5-Di-tert-butyl-4-hydroxy-phenyl)-meth-(Z)-ylidene]-1-methyl-4-oxo-4,5-dihydro-1H-imidazol-2-yl}-guanidine

SMILES CN1C(NC(N)=N)=NC(=O)C1=Cc1cc(c(O)c(c1)C(C)(C)C)C(C)(C)C

InChI Key InChIKey=ODJUKFKDSPPDFS-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50044068   

TargetPolyunsaturated fatty acid 5-lipoxygenase(Rattus norvegicus)
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50044068(CHEMBL15904 | N-[5-(3,5-Di-tert-butyl-4-hydroxy-be...)
Affinity DataIC50:  1.30E+3nMAssay Description:Inhibition of 5-lipoxygenase in intact rat basophilic leukemia cells stimulated with the calciumionophore A-23,187More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50044068(CHEMBL15904 | N-[5-(3,5-Di-tert-butyl-4-hydroxy-be...)
Affinity DataIC50:  1.50E+3nMAssay Description:IC50 against Prostaglandin G/H synthase 1 from human platelet rich plasmaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50044068(CHEMBL15904 | N-[5-(3,5-Di-tert-butyl-4-hydroxy-be...)
Affinity DataIC50:  8.10E+4nMAssay Description:IC50 against recombinant human Prostaglandin G/H synthase 2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Mus musculus (Mouse))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50044068(CHEMBL15904 | N-[5-(3,5-Di-tert-butyl-4-hydroxy-be...)
Affinity DataIC50:  750nMAssay Description:IC50 value was determined against Prostaglandin G/H synthase 2 of J7744A.1 cell lines.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Warner-Lambert

Curated by ChEMBL
LigandPNGBDBM50044068(CHEMBL15904 | N-[5-(3,5-Di-tert-butyl-4-hydroxy-be...)
Affinity DataIC50:  27nMAssay Description:IC50 against ovine Prostaglandin G/H synthase 1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed